2. Gene
  3. P2rx3 - purinergic receptor P2X, ligand-gated ion channel, 3 Gene

P2rx3 - purinergic receptor P2X, ligand-gated ion channel, 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X，配体门控离子通道，3

种属: Mus musculus

同用名: P2X3; 4930513E20Rik

基因 ID: 228139 | 基因类型: protein coding

关于 P2rx3

Chromosome 2: 84,828,927-84,867,806 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 275 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in testis adult (RPKM 11.8), CNS E14 (RPKM 1.5) and 2 other tissues.

功能概要

该基因编码的蛋白可启动细胞外 ATP 门控阳离子通道活动。参与化学突触传递的调节。作用于几个过程的上游或内部，包括神经肌肉突触传递；对 ATP 的反应；和平滑肌收缩。位于 Schaffer 侧支 - CA1 突触和轴突。活跃于海马苔藓纤维至 CA3 突触。以多种结构表达，包括鳃弓；胚胎外胚层；神经系统;视网膜；和皮肤。与人 P2RX3（嘌呤能受体 P2X 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables extracellularly ATP-gated cation channel activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within several processes, including neuromuscular synaptic transmission; response to ATP; and smooth muscle contraction. Located in Schaffer collateral - CA1 synapse and axon. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including branchial arch; embryo ectoderm; nervous system; retina; and skin. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]

P2rx3 基因产物(1)

mRNA Protein Name
NM_145526.2 NP_663501.2 P2X purinoceptor 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables extracellularly ATP-gated monoatomic cation channel activity IGI
IGI: 通过遗传相互作用推断
15081800 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within behavioral response to pain IGI
IGI: 通过遗传相互作用推断
15961431 MGI
acts upstream of or within behavioral response to pain IMP
IMP: 通过突变表型推断
11069181 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: 通过突变表型推断
17074061 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
11069181 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
17074061 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
17074061 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: 通过突变表型推断
11069182 MGI
acts upstream of or within monoatomic ion transport IMP
IMP: 通过突变表型推断
11069181 MGI
acts upstream of or within neuromuscular synaptic transmission IMP
IMP: 通过突变表型推断
12813150 MGI
acts upstream of or within peristalsis IMP
IMP: 通过突变表型推断
12813150 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
17074061 MGI
acts upstream of or within response to ATP IGI
IGI: 通过遗传相互作用推断
15961431 MGI
acts upstream of or within response to ATP IMP
IMP: 通过突变表型推断
11069181 MGI
acts upstream of or within response to carbohydrate IMP
IMP: 通过突变表型推断
16322458 MGI
acts upstream of or within response to cold IMP
IMP: 通过突变表型推断
15927378 MGI
acts upstream of or within response to heat IMP
IMP: 通过突变表型推断
15927378 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
14672995 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: 通过突变表型推断
11466438 MGI
acts upstream of or within response to temperature stimulus IMP
IMP: 通过突变表型推断
11069182 MGI
acts upstream of or within sensory perception of taste IGI
IGI: 通过遗传相互作用推断
16322458 MGI
acts upstream of or within urinary bladder smooth muscle contraction IGI
IGI: 通过遗传相互作用推断
15961431 MGI
acts upstream of or within urinary bladder smooth muscle contraction IMP
IMP: 通过突变表型推断
11069181 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
17074061 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
17074061 MGI
located in axon IDA
IDA: 通过直接分析推断
11466438 MGI
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: 通过直接分析推断
17074061 MGI
is active in hippocampal mossy fiber to CA3 synapse IMP
IMP: 通过突变表型推断
17074061 MGI
located in neuron projection IDA
IDA: 通过直接分析推断
11466438 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2rx3 蛋白结构

P2X_receptor

P2X_receptor: pfam00864 (7 - 359)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
蛋白主名 其他名称

P2X purinoceptor 3

ATP receptor

purinergic receptor P2X3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09903 P2RX3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09904 P2rx3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09905 P2rx3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2rx3 NCBI NCBI:5024
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