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  3. P2RX3 - purinergic receptor P2X 3 Gene

P2RX3 - purinergic receptor P2X 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2X 3

种属: Homo sapiens

同用名: P2X3

基因 ID: 5024 | 基因类型: protein coding

关于 P2RX3

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,335,950-57,372,396 (from NCBI)

This gene has 3 transcripts (splice variants), 275 orthologues and 6 paralogues. Biased expression in testis (RPKM 1.0), heart (RPKM 0.8) and 6 other tissues.

功能概要

该基因编码 P2X 嘌呤能受体 (purinoceptor) 基因家族的一个成员，该家族包括七个成员 (P2RX1 - P2RX7) 。 P2X 嘌呤受体是一个阳离子可渗透的配体门控离子通道家族，它响应细胞外腺苷 5'-三磷酸 (ATP) 的结合而打开。编码的蛋白质是三聚体 P2X3 受体离子通道的亚基，由感觉或自主神经元表达。小鼠中直系同源蛋白的缺乏与疼痛相关行为减少和膀胱反射减弱有关。[RefSeq 提供，2017 年 8 月]

This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 Receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]

P2RX3 基因产物(7)

mRNA Protein Name
XR_949950.3
XM_011545069.3 XP_011543371.1 P2X purinoceptor 3 isoform X1
XM_011545073.2 XP_011543375.1 P2X purinoceptor 3 isoform X4
XM_011545071.3 XP_011543373.1 P2X purinoceptor 3 isoform X2
XM_011545072.3 XP_011543374.1 P2X purinoceptor 3 isoform X3
XM_011545070.3 XP_011543372.1 P2X purinoceptor 3 isoform X1
NM_002559.5 NP_002550.2 P2X purinoceptor 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
27626375 GOA
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
27626375 GOA
enables purinergic nucleotide receptor activity IDA
IDA: 通过直接分析推断
27626375 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to ATP IDA
IDA: 通过直接分析推断
27626375 GOA
involved in inorganic cation transmembrane transport IDA
IDA: 通过直接分析推断
27626375 GOA
involved in protein homotrimerization IDA
IDA: 通过直接分析推断
27626375 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IMP
IMP: 通过突变表型推断
27626375 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2RX3 蛋白结构

P2X_receptor

P2X_receptor: ATP P2X receptor (8 - 369)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
蛋白主名 其他名称

P2X purinoceptor 3

ATP receptor

P2X receptor, subunit 3

purinergic receptor P2X, ligand gated ion channel, 3

purinergic receptor P2X3

purinoceptor P2X3

关联疾病

疾病名称 别名
Chronic Interstitial Cystitis
Migraine, Familial Hemiplegic, 1

FHM1

Mhp1

Fhm

Familial Hemiplegic Migraine 1

Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia

Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia

Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia

Migraine, Hemiplegic, Familial, Type 1

Hemiplegic Migraine, Familial Type 1
Migraine With Aura

Classic Migraine

Migraine With Typical Aura

Migraine Accompagnée

Complicated Migraine

Classical Migraine

Acute Migraine With Aura
Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Paine Syndrome

Pain Disorder

Pain

Microcephaly With Spastic Diplegia

Pain Syndrome
Deafness, Autosomal Dominant 41

DFNA41

Autosomal Dominant Nonsyndromic Deafness 41

Autosomal Dominant Deafness 41

Deafness, Autosomal Dominant, 41

Deafness, Autosomal Dominant, Type 41
Reflex Sympathetic Dystrophy

Algodystrophy

Complex Regional Pain Syndrome Type 1

Reflex Sympathetic Dystrophy Syndrome

Complex Regional Pain Syndromes

Algodystrophic Syndrome
Trigeminal Neuralgia

Tic Douloureux

Trifacial Neuralgia

Trifocal Neuralgia

Neuralgia Of The Fifth Cranial Nerve

Neuralgia Of 5th Cranial Nerve

Infraorbital Neuralgia
Complex Regional Pain Syndrome

Complex Regional Pain Syndromes

Reflex Sympathetic Dystrophy

Crps
Chronic Pain
Urethral Syndrome

Urethral Disease

Urethral Diseases

Urethra Disease

Abnormality Of The Urethra

Urethral Disorders
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Erythromelalgia

Primary Erythromelalgia

Erythermalgia

Primary Erythermalgia

Mitchell Disease

Familial Erythromelalgia
Alcoholic Neuropathy

Alcoholic Polyneuropathy

Alcohol-Related Polyneuropathy

Alcohol-Induced Polyneuropathy

Alcoholic Peripheral Neuropathy
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Femoral Cancer

Femoral Neoplasms

Cancer Of The Femur

Femoral Neoplasm

Neoplasm Of Femur
Fibromyalgia

Diffuse Myofascial Pain Syndrome

Fibromyalgia Syndrome

Fibromyalgia-Fibromyositis Syndrome

Fibromyositis

Fibrositis

Fms

Myofascial Pain Syndrome

Myofascial Pain Syndromes
Glossopharyngeal Neuralgia

Glossopharyngeal Nerve Diseases
Ischemic Neuropathy

Ischemic Peripheral Neuropathy
Familial Hemiplegic Migraine

Hemiplegic Migraine, Familial

Hemiplegic-Ophthalmoplegic Migraine

Fhm

Hemiplegic Migraine Familial
Burning Mouth Syndrome

Orodynia

Stomatodynia

Stomatopyrosis

Bms

Burning Mouth Disorder

Oral Dysesthesia

Sore Mouth Syndrome

Bms - [Burning Mouth Syndrome]
Cystitis

Infective Cystitis

Urocystitis

Pyocystitis
Trigeminal Nerve Disease

Trigeminal Nerve Diseases

Disorders Of 5th Cranial Nerve

Disorders Of The Fifth Cranial Nerve
Chronic Cystitis
Cough Variant Asthma
Somatoform Disorder

Physiological Malfunction Arising From Mental Factor

Psychosomatic Disorder

Psychophysiologic Disorders
Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder

Neurogenic Urinary Bladder Disorder

Neuropathic Bladder

Bladder Neurogenic

Urinary Bladder, Neurogenic

Neurogenic Urinary Bladder
Low Compliance Bladder

Overactive Bladder

Hyperactivity Of Bladder

Hypertonic Bladder

Hypertonicity Of Bladder

Low Bladder Compliance

Oab - [Overactive Bladder]
Pain Agnosia

Analgesia
Detrusor Sphincter Dyssynergia

Detrusor And Sphincter Dyssynergia
Interstitial Cystitis

Bladder Pain Syndrome

Painful Bladder Syndrome

Ulcerative Cystitis

Ic/Bps

Ic/Pbs

Interstitial Cystitis/Bladder Pain Syndrome

Interstitial Cystitis/Painful Bladder Syndrome

Cystitis, Interstitial

Chronic Interstitial Cystitis

Pelvic Congestion Syndrome

Trigonitis
Myofascial Pain Syndrome

Myofascial Pain Syndromes

Myofascial Pain Dysfunction Syndrome

Fibromyalgia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09903 P2RX3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09904 P2rx3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09905 P2rx3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus P2RX3 RGD RGD:620253
Felis catus P2RX3 VGNC VGNC:68670
Bos taurus P2RX3 VGNC VGNC:32519
Canis familiaris P2RX3 VGNC VGNC:44209
Mus musculus P2RX3 MGD MGI:1097160
Macaca mulatta P2RX3 VGNC VGNC:75733
Others P2RX3 NCBI
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