FKBP3 - FKBP prolyl isomerase 3 Gene

中文名称：FKBP 脯氨酰异构酶 3

种属: Homo sapiens

同用名: FKBP-3; FKBP25; PPIase; FKBP-25

关于 FKBP3

功能概要

该基因编码的蛋白质是免疫亲和蛋白家族的成员，它在免疫调节和涉及蛋白质折叠和运输的基本细胞过程中发挥作用。这种编码的蛋白质是一种顺反式脯氨酰异构酶，可结合免疫抑制剂 FK506 和雷帕霉素，以及组蛋白脱乙酰酶、转录因子 YY1、酪蛋白激酶 II 和核仁素。它对雷帕霉素的亲和力高于对 FK506 的亲和力，因此可能是雷帕霉素免疫抑制的重要靶分子。[RefSeq 提供，2008 年 9 月]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, Casein Kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]