2. Gene
  3. P2rx2 - purinergic receptor P2X, ligand-gated ion channel, 2 Gene

P2rx2 - purinergic receptor P2X, ligand-gated ion channel, 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X，配体门控离子通道，2

种属: Mus musculus

同用名: P2x2; P2X2a

基因 ID: 231602 | 基因类型: protein coding

关于 P2rx2

Chromosome 5: 110,487,678-110,491,078 reverse strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 8 phenotypes. Biased expression in testis adult (RPKM 29.2), genital fat pad adult (RPKM 19.6) and 5 other tissues.

功能概要

该基因编码的蛋白可启动细胞外 ATP 门控阳离子通道活动。参与声音的感官知觉。在多个流程的上游或内部采取行动，包括对 ATP 的响应；骨骼肌纤维发育；和平滑肌收缩。位于质膜。表达于面部神经节；心;延髓基底板地幔层；和迷走神经节。该基因的人类直系同源物与常染色体显性非综合征性耳聋 41 相关。与人类 P2RX2（嘌呤能受体 P2X 2）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables extracellularly ATP-gated cation channel activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including response to ATP; skeletal muscle fiber development; and smooth muscle contraction. Located in plasma membrane. Is expressed in facial ganglion; heart; medulla oblongata basal plate mantle layer; and vagus ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Apr 2022]

P2rx2 基因产物(5)

mRNA Protein Name
NM_001164834.1 NP_001158306.1 P2X purinoceptor 2 isoform c
NM_001310700.1 NP_001297629.1 P2X purinoceptor 2 isoform d
NM_001164833.1 NP_001158305.1 P2X purinoceptor 2 isoform b
NM_153400.4 NP_700449.2 P2X purinoceptor 2 isoform a
NM_001310701.1 NP_001297630.1 P2X purinoceptor 2 isoform e
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
12917379 MGI
enables extracellularly ATP-gated monoatomic cation channel activity IGI
IGI: 通过遗传相互作用推断
15081800 MGI
enables extracellularly ATP-gated monoatomic cation channel activity IMP
IMP: 通过突变表型推断
15081800 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within behavioral response to pain IGI
IGI: 通过遗传相互作用推断
15961431 MGI
acts upstream of or within behavioral response to pain IMP
IMP: 通过突变表型推断
15961431 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: 通过突变表型推断
12917379 MGI
acts upstream of or within detection of hypoxic conditions in blood by carotid body chemoreceptor signaling IMP
IMP: 通过突变表型推断
14672995 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: 通过突变表型推断
17706883 MGI
acts upstream of or within neuromuscular synaptic transmission IMP
IMP: 通过突变表型推断
12937291 MGI
acts upstream of or within peristalsis IMP
IMP: 通过突变表型推断
12937291 MGI
acts upstream of or within response to ATP IGI
IGI: 通过遗传相互作用推断
15961431 MGI
acts upstream of or within response to ATP IMP
IMP: 通过突变表型推断
15572362 MGI
acts upstream of or within response to carbohydrate IMP
IMP: 通过突变表型推断
16322458 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
14672995 MGI
involved in sensory perception of sound IMP
IMP: 通过突变表型推断
23345450 MGI
acts upstream of or within sensory perception of taste IGI
IGI: 通过遗传相互作用推断
16322458 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: 通过突变表型推断
17706883 MGI
acts upstream of or within urinary bladder smooth muscle contraction IGI
IGI: 通过遗传相互作用推断
15961431 MGI
acts upstream of or within urinary bladder smooth muscle contraction IMP
IMP: 通过突变表型推断
15961431 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
15961431 MGI
is active in neuronal dense core vesicle EXP
EXP: 通过实验结果推断
21321602 MGI
is active in neuronal dense core vesicle IDA
IDA: 通过直接分析推断
21321602 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17706883 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2rx2 蛋白结构

P2X

P2X: TIGR00863 (13 - 379)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
蛋白主名 其他名称

P2X purinoceptor 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09900 P2RX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09901 P2rx2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09902 P2rx2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2rx2 NCBI NCBI:22953
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