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  2. ZC3H4 - zinc finger CCCH-type containing 4 Gene

ZC3H4 - zinc finger CCCH-type containing 4 Gene

中文名称:含锌指 CCCH 型 4

种属: Homo sapiens

同用名: C19orf7

基因 ID: 23211 | 基因类型: protein coding

关于 ZC3H4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:47,064,187-47,113,776 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 3.8), ovary (RPKM 2.9) and 25 other tissues.

功能概要

该基因编码 CCCH (C-x8-C-x5-C-x3-H 型) 锌指结构域蛋白家族的成员。这些协调锌指结合并以三个半胱氨酸残基和一个组氨酸残基为特征的锌指结构域是核酸结合的。已知其他家族成员在转录后调控中发挥作用。[RefSeq 提供,2011 年 8 月]

This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]

ZC3H4 基因产物(1)

mRNA Protein Name
NM_015168.2 NP_055983.1 zinc finger CCCH domain-containing protein 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
33913806 GOA
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
33913806 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
33913806 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lncRNA catabolic process IDA
IDA: 通过直接分析推断
33913806 GOA
involved in negative regulation of DNA-templated transcription, elongation IDA
IDA: 通过直接分析推断
33913806 GOA
involved in negative regulation of lncRNA transcription IDA
IDA: 通过直接分析推断
33913806 GOA
involved in nuclear RNA surveillance IDA
IDA: 通过直接分析推断
33913806 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZC3H4 蛋白结构

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (420 - 444)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1303 a.a.
蛋白主名 其他名称

zinc finger CCCH domain-containing protein 4

关联疾病

疾病名称 别名
Pulmonary Talcosis

Pneumoconiosis Due To Talc

Talc Pneumoconiosis

Talcosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ZC3H4 VGNC VGNC:48559
Felis catus ZC3H4 VGNC VGNC:67186
Mus musculus ZC3H4 MGD MGI:2682314
Rattus norvegicus ZC3H4 RGD RGD:1596943
Bos taurus ZC3H4 VGNC VGNC:37106
Macaca mulatta ZC3H4 VGNC VGNC:79094