1. Gene
  2. CLEC16A - C-type lectin domain containing 16A Gene

CLEC16A - C-type lectin domain containing 16A Gene

中文名称:含 C 型凝集素结构域 16A

种属: Homo sapiens

同用名: Gop-1; KIAA0350

基因 ID: 23274 | 基因类型: protein coding

关于 CLEC16A

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:10,944,564-11,182,186 (from NCBI)

This gene has 14 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 11.3), brain (RPKM 3.5) and 24 other tissues.

功能概要

该基因编码含有 C 型凝集素结构域的家族成员。该基因内含子中的单核苷酸多态性与糖尿病、多发性硬化症和类风湿性关节炎有关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2011 年 8 月]

This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

CLEC16A 基因产物(3)

mRNA Protein Name
NM_001243403.2 NP_001230332.1 protein CLEC16A isoform 2
NM_001410905.1 NP_001397834.1 protein CLEC16A isoform 3
NM_015226.3 NP_056041.1 protein CLEC16A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
36538041 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to starvation IMP
IMP: 通过突变表型推断
28223137 GOA
involved in mitophagy IDA
IDA: 通过直接分析推断
35604110 GOA
involved in negative regulation of autophagosome maturation IMP
IMP: 通过突变表型推断
28223137 GOA
involved in positive regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
28223137 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
28223137 GOA
located in cytosol IDA
IDA: 通过直接分析推断
28223137 GOA
located in vesicle IDA
IDA: 通过直接分析推断
28223137 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CLEC16A 蛋白结构

FPL

FPL: Uncharacterised conserved protein (51 - 199)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1053 a.a.
蛋白主名 其他名称

protein CLEC16A

C-type lectin domain family 16 member A

关联疾病

疾病名称 别名
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Immunoglobulin A Deficiency 1

Immunoglobulin A Deficiency

Selective Iga Deficiency Disease

Selective Immunoglobulin A Deficiency

IGAD1

Immunoglobulin A, Selective Deficiency Of

Iga, Selective Deficiency Of

Gamma-A-Globulin, Selective Deficiency Of

Selective Iga Immunodeficiency

Selective Iga Deficiency

Iga Deficiency Selective

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Selective Immunoglobulin Deficiency Disease
Alopecia Areata

Aa

Alopecia Celsi

Alopecia Circumscripta

Cazenave'S Vitiligo

Celsus' Vitiligo

Diffuse Alopecia

Jonston'S Alopecia

Marginal Alopecia

Pseudopelade

Circumscribed Alopecia

Alopecia Cicatrisata

Patchy Alopecia

Alopecia

Aa - [Alopecia Areata]

Pelade

Diabetes Mellitus

Diabetes

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Dysgammaglobulinemia
Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CLEC16A VGNC VGNC:39328
Bos taurus CLEC16A VGNC VGNC:27426
Felis catus CLEC16A VGNC VGNC:60944
Macaca mulatta CLEC16A VGNC VGNC:71369
Rattus norvegicus CLEC16A RGD RGD:1305773
Mus musculus CLEC16A MGD MGI:1921624