ATP1B4 - ATPase Na+/K+ transporting family member beta 4 Gene

中文名称：ATPase Na+/K+ 转运家族成员 beta 4

种属: Homo sapiens

关于 ATP1B4

功能概要

该基因已在迄今为止测序的所有脊椎动物基因组中发现。然而，与其他物种相比，该基因在胎盘哺乳动物中的功能发生了变化。具体而言，在鱼类、鸟类和两栖动物物种中，该基因编码 Na,K-ATP 酶的质膜结合 β 亚基。在胎盘哺乳动物中，编码的蛋白质与核转录共调节因子 SKIP 相互作用，可能参与 TGF-β 信号转导的调节。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2010 年 3 月]

This gene has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]