2. Gene
  3. SEC11A - SEC11 homolog A, signal peptidase complex subunit Gene

SEC11A - SEC11 homolog A, signal peptidase complex subunit Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SEC11 同系物 A，信号肽酶复合亚基

种属: Homo sapiens

同用名: SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik

基因 ID: 23478 | 基因类型: protein coding

关于 SEC11A

Cytogenetic location: 15q25.2-q25.3 Genomic coordinates (GRCh38): 15:84,669,544-84,716,139 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 67.9), fat (RPKM 55.2) and 25 other tissues.

功能概要

该基因编码肽酶 S26B 家族的一个成员。编码的蛋白质是信号肽酶复合物的一个 18kDa 亚基，与细胞迁移和侵袭、胃癌和淋巴结转移有关。可变剪接导致多个转录本变体。已在 8 号染色体上鉴定出一个相关的假基因。[RefSeq 提供，2012 年 12 月]

This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric Cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]

SEC11A 基因产物(6)

mRNA Protein Name
NM_001271918.2 NP_001258847.1 signal peptidase complex catalytic subunit SEC11A isoform 5
NM_001271919.2 NP_001258848.1 signal peptidase complex catalytic subunit SEC11A isoform 6
NM_001271920.2 NP_001258849.1 signal peptidase complex catalytic subunit SEC11A isoform 4
NM_001271921.2 NP_001258850.1 signal peptidase complex catalytic subunit SEC11A isoform 1
NM_001271922.2 NP_001258851.1 signal peptidase complex catalytic subunit SEC11A isoform 3
NM_014300.4 NP_055115.1 signal peptidase complex catalytic subunit SEC11A isoform 2

SEC11A 蛋白结构

Peptidase_S24

Peptidase_S24: Peptidase S24-like (52 - 104)

  • 0
  • 100
  • 179 a.a.
蛋白主名 其他名称

signal peptidase complex catalytic subunit SEC11A

SEC11-like protein 1

SEC11A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SEC11A P67812 ADAM33 Homo sapiens Q08AM2
Validated Y2H
32296183
Intra SEC11A P67812 SPCS3 Homo sapiens P61009
Anti Tag CoIP
34388369
Intra SEC11A P67812 SPCS3 Homo sapiens P61009
Crosslink
34388369
Intra SEC11A P67812 SPCS3 Homo sapiens P61009
SLCA
34388369
Intra SEC11A P67812 SPCS3 Homo sapiens P61009
Anti Tag CoIP
33961781
Intra SEC11A P67812 SPCS3 Homo sapiens P61009
3D-EM
34388369
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12603 SEC11A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SEC11A VGNC VGNC:80851
Macaca mulatta SEC11A VGNC VGNC:99235
Bos taurus SEC11A VGNC VGNC:53951
Mus musculus SEC11A MGD MGI:1929464
Rattus norvegicus SEC11A RGD RGD:69360
Canis familiaris SEC11A VGNC VGNC:53239
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