FOLR1 - folate receptor alpha Gene

中文名称：叶酸受体α

种属: Homo sapiens

同用名: FBP; FOLR; NCFTD; FRalpha

基因 ID: 2348 | 基因类型: protein coding

关于 FOLR1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,189,709-72,196,323 (from NCBI)

This gene has 5 transcripts (splice variants), 222 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in lung (RPKM 83.5), kidney (RPKM 59.8) and 4 other tissues.

功能概要

该基因编码的蛋白质是叶酸受体家族的成员。该基因家族的成员结合叶酸及其还原衍生物，并将 5-甲基四氢叶酸转运到细胞中。该基因产物是一种分泌蛋白，可通过糖基-磷脂酰肌醇键固定在膜上或以可溶形式存在。该基因的突变与脑叶酸转运缺陷引起的神经变性有关。由于存在两个启动子、多个转录起始位点和可变剪接，已发现该基因编码同一蛋白质的多个转录变体。[RefSeq 提供，2009 年 10 月]

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

FOLR1 基因产物(4)

mRNA	Protein	Name
NM_000802.3	NP_000793.1	folate receptor alpha precursor
NM_016724.3	NP_057936.1	folate receptor alpha precursor
NM_016725.3	NP_057937.1	folate receptor alpha precursor
NM_016729.3	NP_057941.1	folate receptor alpha precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables folic acid binding	IDA IDA: 通过直接分析推断	2527252	GOA
enables folic acid receptor activity	IMP IMP: 通过突变表型推断	8033114	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to folic acid	IDA IDA: 通过直接分析推断	14722620	GOA
involved in folic acid transport	IMP IMP: 通过突变表型推断	8033114	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	10787414	GOA
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	10787414	GOA
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	2527252	GOA
located in nucleus	IDA IDA: 通过直接分析推断	23243496	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOLR1 蛋白结构

Folate_rec

0
100
200
257 a.a.

蛋白主名

其他名称

folate receptor alpha

FR-alpha

FOLR1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FOLR1	P15328	SLC35F6	Homo sapiens	Q8N357	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FOLR1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70296	FOLR1 Protein, Human (HEK293, His)	P15328 (R25-S234)	≥95%
HY-P72371	FOLR1 Protein, Human (Biotinylated, HEK293, His-Avi)	P15328 (R25-S234)	≥95%
HY-P78445	FOLR1 Protein, Human (HEK293, His-Avi)	P15328 (R25-M233)	≥95%

关联疾病

疾病名称

别名

Neurodegeneration Due To Cerebral Folate Transport Deficiency

Cerebral Folate Transport Deficiency	Cerebral Folate Deficiency
NCFTD	Cerebral Folate Deficiency Syndrome
Folr1 Deficiency	Neurodegenerative Syndrome Due To Cerebral Folate Transport Deficiency

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Myelomeningocele

Meningomyelocele

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Choriocarcinoma Of The Testis

Testicular Choriocarcinoma

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption	Congenital Defect Of Folate Absorption
Congenital Folate Malabsorption	Folic Acid Transport Defect
HFM

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Fallopian Tube Adenocarcinoma

Adenocarcinoma Of The Fallopian Tube

Leukodystrophy

Leukodystrophies

Serine Deficiency

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD	Charcot-Marie-Tooth Neuropathy, Type 2dd
Charcot-Marie-Tooth Disease Type 2dd	Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Atp1a1-Related Cmt2	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd
Charcot-Marie-Tooth Disease 2dd

Epilepsy, Pyridoxine-Dependent

Pyridoxine-Dependent Epilepsy	PDE
Pyridoxine Dependency With Seizures	Vitamin B6-Dependent Seizures
EPD	Aasa Dehydrogenase Deficiency
Antiquitin Deficiency	Pyridoxine Dependency
Glutamate Decarboxylase Deficiency	Pyridoxine-Dependent Seizures
Deficiency Of Glutamate Decarboxylase

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-132258A	Mirvetuximab soravtansine (solution)		99.71%	Phase 2

目录号	产品名	作用方式	纯度	Phase
HY-P99225	Mirvetuximab		99.88%	Phase 3

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05029	FOLR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	FOLR1	VGNC	VGNC:102889
Macaca mulatta	FOLR1	VGNC	VGNC:72689
Rattus norvegicus	FOLR1	RGD	RGD:71032
Mus musculus	FOLR1	MGD	MGI:95568
Canis familiaris	FOLR1	NCBI
Macaca fascicularis	FOLR1	NCBI	NCBI:102132305
Others	FOLR1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FOLR1 - folate receptor alpha Gene

关于 FOLR1

功能概要

FOLR1 基因产物(4)

FOLR1 蛋白结构

FOLR1 蛋白互作信息

重组 FOLR1 蛋白

关联疾病

直系同源

热门区域

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FOLR1 - folate receptor alpha Gene

关于 FOLR1

功能概要

FOLR1 基因产物(4)

FOLR1 蛋白结构

FOLR1 蛋白互作信息

重组 FOLR1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z