2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Antifolate
  4. Mirvetuximab soravtansine (solution)

Mirvetuximab soravtansine (solution)  (Synonyms: IMGN853 (solution))

目录号: HY-132258A 纯度: 99.71%
COA 产品使用指南

摩尔计算器

Mirvetuximab soravtansine (IMGN853) solution 是一种抗-叶酸受体 α (FRα) 的抗体药物偶联物 (ADC)，由细胞毒性 maytansoid DM4 组成，共价连接到人源化单克隆抗体 M9346A。Mirvetuximab soravtansine 选择性结合叶酸受体1 (FOLR1)。Mirvetuximab soravtansine 具有抑制生长和增强 DNA 损伤的抗增殖作用。

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Mirvetuximab soravtansine (solution) Chemical Structure

Mirvetuximab soravtansine (solution) Chemical Structure

CAS No. : 1453084-37-1

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规格 价格 是否有货 数量
1 mg (10.246 mg/mL * 97.6 μL in 10mM Histidine pH=5.5) ￥7500
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Other Forms of Mirvetuximab soravtansine (solution):

Mirvetuximab soravtansine (solution) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

Mirvetuximab soravtansine (IMGN853) solution is an anti-folate receptor α (FRα) antibody drug-conjugate (ADC) consisting of the cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A. Mirvetuximab soravtansine selectively binds to folate receptor 1 (FOLR1). Mirvetuximab soravtansine has an anti-proliferative effect via growth arrest and augmented DNA damage[1].

体外研究
(In Vitro)

Mirvetuximab soravtansine (IMGN853; 8 nM; 6 h; IGROV-1 细胞) 与 Carboplatin (HY-17393) 的结合在体外促进协同生长抑制作用和细胞周期扰动[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mirvetuximab soravtansine (solution) 相关抗体:
体内研究
(In Vivo)

Mirvetuximab soravtansine (IMGN853; 5 mg/kg; i.v.; SCID 雌性小鼠患者来源的异种移植模型) 增强 Carboplatin 的体内抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

150000 (average)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light
纯度 & 产品资料

纯度: 99.71%

COA (266 KB) SEC-HPLC (142 KB)

产品使用指南 (1538 KB)

Mirvetuximab soravtansine (solution) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mirvetuximab soravtansine (solution)1453084-37-1IMGN853 (solution)Antibody-Drug Conjugates (ADCs)AntifolateAntibody-Drug ConjugatesInhibitorinhibitorinhibit

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