PIK3R5 - phosphoinositide-3-kinase regulatory subunit 5 Gene

中文名称：磷酸肌醇 3 激酶调节亚基 5

种属: Homo sapiens

同用名: p101; FOAP-2; P101-PI3K; F730038I15Rik

关于 PIK3R5

功能概要

磷脂酰肌醇 3-激酶 (PI3Ks) 磷酸化磷脂酰肌醇的肌醇环的 3-主要位置，并在细胞生长、增殖、分化、运动、存活和细胞内运输中发挥重要作用。 PI3K 分为三类：I、II 和 III，只有 I 类 PI3K 参与肿瘤发生。该基因编码 I 类 PI3K γ 复合物的 101 kD 调节亚基，这是一种二聚酶，由一个 110 kD 催化亚基 γ 和一个 55、87 或 101 kD 的调节亚基组成。这种蛋白质通过与 G-β-γ 蛋白的高亲和力相互作用，将催化亚基从胞质溶胶募集到质膜。已发现编码两种不同亚型的多个选择性剪接转录物变体。[RefSeq 提供，2011 年 10 月]

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric Enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]