2. Gene
  3. CHST5 - carbohydrate sulfotransferase 5 Gene

CHST5 - carbohydrate sulfotransferase 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：碳水化合物磺基转移酶 5

种属: Homo sapiens

同用名: gn6st-3; hIGn6ST; I-GlcNAc6ST; glcNAc6ST-3; I-GlcNAc-6-ST

基因 ID: 23563 | 基因类型: protein coding

关于 CHST5

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,528,530-75,536,108 (from NCBI)

This gene has 2 transcripts (splice variants), 71 orthologues and 6 paralogues. Biased expression in colon (RPKM 16.2), duodenum (RPKM 16.2) and 2 other tissues.

功能概要

该基因编码的蛋白质属于 Gal/GalNAc/GlcNAc 6-O-磺基转移酶 (GST) 家族，其成员催化硫酸盐转移到半乳糖 (Gal) 、N-乙酰半乳糖胺 (GalNAc) 或 N 的第 6 位蛋白聚糖中的乙酰氨基葡萄糖 (GlcNAc) 残基，以及粘蛋白型受体的 O-连接糖的硫酸化。碳水化合物硫酸化在许多生物过程中起着至关重要的作用。该基因主要在结肠和小肠中表达。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]

CHST5 基因产物(1)

mRNA Protein Name
NM_024533.5 NP_078809.2 carbohydrate sulfotransferase 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-acetylglucosamine 6-O-sulfotransferase activity IDA
IDA: 通过直接分析推断
10491328 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-acetylglucosamine metabolic process IDA
IDA: 通过直接分析推断
10491328 GOA
involved in sulfur compound metabolic process IDA
IDA: 通过直接分析推断
10491328 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
12855678 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHST5 蛋白结构

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (64 - 378)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
蛋白主名 其他名称

carbohydrate sulfotransferase 5

GST4-alpha

关联疾病

疾病名称 别名
Macular Dystrophy, Corneal

Macular Corneal Dystrophy

MCD

Corneal Dystrophy, Macular Type

Groenouw Type Ii Corneal Dystrophy

Fehr Corneal Dystrophy

Macular Dystrophy, Corneal Type 1

Mcdc1

Macular Corneal Dystrophy Type Ii

Macular Corneal Dystrophy, Type Ii

Macular Corneal Dystrophy, Type I

Mcdc1, Formerly

Macular Dystrophy, Corneal, 1

Macular Corneal Dystrophy Type 1

Corneal Dystrophy Groenouw Type Ii

Corneal Dystrophy Macular Type

Macular Corneal Dystrophy Type I

Dystrophy, Macular, Corneal
Corneal Dystrophy, Groenouw Type I

CDGG1

Gcd1

Groenouw Corneal Dystrophy Type I

Granular Corneal Dystrophy 1

Granular Corneal Dystrophy Type I

Corneal Dystrophy Groenouw Type I

Granular Corneal Dystrophy, Type I

Corneal Dystrophy, Punctate Or Nodular

Groenouw Type I Corneal Dystrophy

Corneal Dystrophy Granular Type

Corneal Dystrophy Punctate Or Nodular

Classic Gcd

Classic Granular Corneal Dystrophy

Gcdi

Granular Corneal Dystrophy Type 1

Corneal Dystrophy, Groenouw Type 1

Mesh

D003317

Punctate Or Nodular Corneal Dystrophy

Dystrophy, Corneal, Groenouw Type I
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 1

Xylosylprotein 4-Beta-Galactosyltransferase Deficiency

Xgpt Deficiency

EDSSPD1

Ehlers-Danlos Syndrome With Short Stature And Limb Anomalies

Edssla

Proteodermatan Sulfate, Defective Biosynthesis Of

Pds, Defective Biosynthesis Of

Dermatan Sulfate Proteoglycan

Galactosyltransferase I Deficiency

Ehlers-Danlos Syndrome Spondylodysplastic Type 1

Spondylodysplastic Ehlers-Danlos Syndrome

Ehlers-Danlos Syndrome, Progeroid Type, 1, Formerly

Edsp1, Formerly

Ehlers-Danlos Syndrome, Progeroid Type

Galactosyltransferase 1 Deficiency

Spondylodysplastic Eds

Speds

Defective Biosynthesis Of Pds

Defective Biosynthesis Of Proteodermatan Sulfate

Edsp1

Ehlers-Danlos Syndrome, Progeroid Type, 1

Proteodermatan Sulfate Defective Biosynthesis Of

Ehlers-Danlos, Spondylodysplastic Syndrome

Ehlers-Danlos Syndrome, Progeroid Form
Joubert Syndrome 20

JBTS20

Joubert Syndrome, Type 20
Blepharochalasis

Dermatolysis Palpebrarum

Adiposa Ptosis
Stromal Dystrophy
Corneal Dystrophy, Lisch Epithelial

Lisch Epithelial Corneal Dystrophy

LECD

Band-Shaped And Whorled Microcystic Corneal Epithelial Dystrophy

Band-Shaped And Whorled Microcystic

Band-Shaped And Whorled Microcystic Dystrophy Of The Corneal Epithelium
Spondyloepiphyseal Dysplasia, Kimberley Type

SEDK

Spondyloepiphyseal Dysplasia Kimberley Type

Spondyloepiphyseal Dysplasia Type Kimberley

Dysplasia, Spondyloepiphyseal, Kimberley Type
Granular Corneal Dystrophy

Granular Dystrophy Corneal

Corneal Dystrophies, Hereditary

Hereditary Corneal Dystrophy

Corneal Dystrophy Nos

Familial Hereditary Corneal Degeneration

Hereditary Corneal Opacity
Sorsby Fundus Dystrophy

SFD

Fundus Dystrophy, Pseudoinflammatory, Of Sorsby

Sorsby'S Fundus Dystrophy

Macular Dystrophy, Hemorrhagic

Hemorrhagic Macular Dystrophy

Pseudoinflammatory Fundus Dystrophy Of Sorsby

Sorsby'S Pseudoinflammatory Macular Dystrophy

Sorsby Pseudoinflammatory Fundus Dystrophy

Dystrophy, Fundus, Sorsby
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-E70165 Carbohydrate Sulfotransferase 5 / 否
HY-RS02691 CHST5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CHST5 MGD MGI:1931825
Others CHST5 NCBI
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