CASP14 - caspase 14 Gene

中文名称：半胱天冬酶 14

种属: Homo sapiens

同用名: ARCI12

基因 ID: 23581 | 基因类型: protein coding

关于 CASP14

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,049,480-15,058,293 (from NCBI)

This gene has 2 transcripts (splice variants), 179 orthologues, 16 paralogues and is associated with 1 phenotype. Restricted expression toward skin (RPKM 223.1).

功能概要

该基因编码半胱氨酸-天冬氨酸蛋白酶 (半胱天冬酶) 家族的成员。半胱天冬酶的顺序激活在细胞凋亡的执行阶段起着核心作用。半胱天冬酶作为无活性的酶原存在，其在保守的天冬氨酸残基处进行蛋白水解加工以产生大小两个亚基，它们二聚化形成活性酶。这种半胱天冬酶已显示在体外被半胱天冬酶 8 和半胱天冬酶 10 加工和激活，并在体内被抗 Fas 激动剂抗体或 TNF 相关细胞凋亡诱导配体加工和激活。这种半胱天冬酶的表达和加工可能参与角质形成细胞终末分化，这对皮肤屏障的形成很重要。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell Apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active Enzyme. This Caspase has been shown to be processed and activated by Caspase 8 and Caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related Apoptosis inducing ligand in vivo. The expression and processing of this Caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]

CASP14 基因产物(1)

mRNA	Protein	Name
NM_012114.3	NP_036246.1	caspase-14 precursor

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24872419	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	23377137	GOA
located in nucleus	IDA IDA: 通过直接分析推断	23377137	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CASP14 蛋白结构

Peptidase_C14

0
100
200
242 a.a.

蛋白主名

其他名称

caspase-14

CASP-14

CASP14 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CASP14	P31944	PSAP	Homo sapiens	P07602	Pull Down	24872419
种属内	CASP14	P31944	PSAP	Homo sapiens	P07602	PLA	24872419
种属内	CASP14	P31944	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
种属内	CASP14	P31944	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CASP14 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7743	Caspase-14/CASP14 Protein, Human (His)	P31944 (S2-Q242)	≥95%

CASP14 抗体

目录号	产品名	应用	反应物种
HY-P83435	Caspase 14 Antibody (YA3180)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Ichthyosis, Congenital, Autosomal Recessive 12

ARCI12

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Type 1 Diabetes Mellitus 17

Diabetes Mellitus, Insulin-Dependent, 17	Iddm17
Insulin-Dependent Diabetes Mellitus 17	TID17
Insulin-Dependent Diabetes Mellitus-17

Ichthyosis Vulgaris

Ichthyosis Simplex	Dominant Congenital Ichthyosiform Erythroderma
Common Ichthyosis	Fish Scale Disease
VI	Ichthyoses
Congenital Ichthyosis

Ichthyosis, Congenital, Autosomal Recessive 1

Collodion Fetus	Autosomal Recessive Congenital Ichthyosis 1
ARCI1	Ichthyosis Congenita
Lamellar Exfoliation Of Newborn	Desquamation Of Newborn
Ichthyosis Congenita Ii	Shcb
Icr2	Bathing Suit Ichthyosis
Li1	Self-Healing Collodion Baby
Ichthyosis, Congenital, Autosomal Recessive 1, With Bathing Suit Distribution	Collodion Baby, Self-Healing
Ichthyosis, Lamellar, 1, Formerly	Li1, Formerly
Ichthyosis Lamellar 1	Lamellar Ichthyosis, Type 1
Bsi	Autosomal Recessive Congenital Ichthyosis 1 With Bathing Suit Distribution
Autosomal Recessive Congenital Ichthyosis Tgm1-Related	Lamellar Ichthyosis 1
Non-Erythrodermic Ichthyosis	Ichthyosis, Congenital, Autosomal Recessive, Type 1
Congenital Ichthyosis

Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis	Autosomal Recessive Congenital Ichthyosis 4b
Hi	Harlequin Fetus
ARCI4B	Ichthyosis Congenita, Harlequin Fetus Type
Harlequin Type Ichthyosis	'Harlequin Fetus'
Harlequin Type Ichthyosis Congenita	Harlequin Type Ichthyosis Fetalis
Harlequin Baby Syndrome	Ichthyosis Congenita, Harlequin Type
Ichthyosis Fetalis, Harlequin Type	Ichthyosis Congenita Harlequin Fetus Type
Ichthyosis, Harlequin	Ichthyosis, Congenital, Autosomal Recessive, Type 4b

Psoriasis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01948	CASP14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CASP14	VGNC	VGNC:38732
Macaca mulatta	CASP14	VGNC	VGNC:70542
Felis catus	CASP14	VGNC	VGNC:60380
Mus musculus	CASP14	MGD	MGI:1335092
Bos taurus	CASP14	VGNC	VGNC:26779
Rattus norvegicus	CASP14	RGD	RGD:1311781
Others	CASP14	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CASP14 - caspase 14 Gene

关于 CASP14

功能概要

CASP14 基因产物(1)

CASP14 蛋白结构

CASP14 蛋白互作信息

重组 CASP14 蛋白

CASP14 抗体

关联疾病

直系同源

热门区域

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CASP14 - caspase 14 Gene

关于 CASP14

功能概要

CASP14 基因产物(1)

CASP14 蛋白结构

CASP14 蛋白互作信息

重组 CASP14 蛋白

CASP14 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z