1. Gene
  2. PRND - prion like protein doppel Gene

PRND - prion like protein doppel Gene

中文名称:朊病毒样蛋白双倍体

种属: Homo sapiens

同用名: DPL; PrPLP; DOPPEL; dJ1068H6.4

基因 ID: 23627 | 基因类型: protein coding

关于 PRND

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:4,721,909-4,728,460 (from NCBI)

This gene has 1 transcript (splice variant) and 76 orthologues. Restricted expression toward testis (RPKM 54.6).

功能概要

该基因位于 20 号染色体上,位于编码细胞朊蛋白的基因下游约 20 kbp 处,在生化和结构上与其相似。由该基因编码的蛋白质是一种膜糖基磷脂酰肌醇锚定糖蛋白,主要存在于睾丸中。该基因的突变可能导致神经系统疾病。[RefSeq 提供,2008 年 7 月]

This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]

PRND 基因产物(1)

mRNA Protein Name
NM_012409.4 NP_036541.2 prion-like protein doppel preproprotein
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables copper ion binding IDA
IDA: 通过直接分析推断
20411530 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
12200435 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PRND 蛋白结构

Doppel

Doppel: Prion-like protein Doppel (1 - 30)

Prion

Prion: Prion/Doppel alpha-helical domain (63 - 176)

  • 0
  • 100
  • 176 a.a.
蛋白主名 其他名称

prion-like protein doppel

downstream prion protein-like

重组 PRND 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71236 PRND Protein, Human (HEK293, His) Q9UKY0 (R27-G152) ≥95%

关联疾病

疾病名称 别名
Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease

CJD

Bovine Spongiform Encephalopathy

Vcjd

Inherited Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease, Familial

Creutzfeldt Jakob Disease

Creutzfeldt-Jacob Disease

Creutzfeldt Jacob Disease

Sporadic Creutzfeldt-Jakob Disease

Encephalopathy, Bovine Spongiform

Creutzfeldt-Jakob Disease, Variant, Resistance To

Creutzfeldt-Jakob Disease, Variant

Creutzfeldt Jacob Syndrome

Jakob-Creutzfeldt Disease

Subacute Spongiform Encephalopathy

Transmissible Virus Dementia

New Variant Of Cjd

Nv-Cjd

Variant Cjd

Variant Creutzfeldt-Jacob Disease

Sporadic Cjd

Inherited Cjd

Acquired Creutzfeldt-Jakob Disease

Variant Mcj

Encephalopathy Bovine Spongiform

Familial Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Syndrome

New Variant Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease, Sporadic

Acquired Cjd

Scjd - [Sporadic Creutzfeldt-Jakob Disease]

Idiopathic Creutzfeldt-Jakob Disease

Creutzfeld-Jakob Disease Nos

Vcjd - [Variant Creutzfeldt-Jakob Disease]

Scrapie
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited

Microcephaly 7, Primary, Autosomal Recessive

MCPH7

Primary Autosomal Recessive Microcephaly 7

Microcephaly, Primary Autosomal Recessive, 7

Chronic Wasting Disease

Wasting Disease, Chronic

Fatal Familial Insomnia

Insomnia, Fatal Familial

FFI

Familial Fatal Insomnia

Insomnia Familial Fatal

Insomnia Fatal Familial

Insomnia, Fatal, Familial

Ffi - [Fatal Familial Insomnia]

Kuru

Kuru, Susceptibility To

Kuru Encephalopathy

Kuru Encephalitis

Kuru Disease

Gerstmann-Straussler Disease

Gerstmann-Straussler-Scheinker Disease

Gerstmann-Straussler-Scheinker Syndrome

Prion Dementia

Cerebral Amyloid Angiopathy, Prnp-Related

GSD

Gss

Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns

Amyloidosis, Cerebral, With Spongiform Encephalopathy

Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type

Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type

Amyloidosis Cerebral With Spongiform Encephalopathy

Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System

Encephalopathy Subacute Spongiform Gerstmann-Straussler Type

Gssd

Gerstmann Straussler Scheinker Syndrome

Cerebral Amyloidosis With Spongiform Encephalopathy

Subacute Spongiform Encephalopathy Gerstmann-Straussler Type

Gluthathione Synthetase Deficiency

Gerstmann Straussler Syndrome

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRND MGD MGI:1346999
Canis familiaris PRND VGNC VGNC:45003
Bos taurus PRND VGNC VGNC:33355
Felis catus PRND VGNC VGNC:64364
Rattus norvegicus PRND RGD RGD:1306618
Others PRND NCBI