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  2. Map2k5 - mitogen-activated protein kinase kinase 5 Gene

Map2k5 - mitogen-activated protein kinase kinase 5 Gene

中文名称:丝裂原活化蛋白激酶激酶 5

种属: Mus musculus

同用名: MEK5; Mapkk5; Prkmk5

基因 ID: 23938 | 基因类型: protein coding

关于 Map2k5

Chromosome 9: 63,071,050-63,285,184 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 209 orthologues, 8 paralogues and is associated with 11 phenotypes. Ubiquitous expression in adrenal adult (RPKM 1.5), thymus adult (RPKM 8.4) and 28 other tissues.

功能概要

预测该基因编码的蛋白可启动 ATP 结合活性和 MAP 激酶激酶活性。在 MAPK 级联和心脏发育的上游或内部起作用。位于主轴。在孕早期表达;卵母细胞;和端脑。与人 MAP2K5(丝裂原活化蛋白激酶激酶 5)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable ATP binding activity and MAP kinase kinase activity. Acts upstream of or within MAPK cascade and heart development. Located in spindle. Is expressed in early conceptus; oocyte; and telencephalon. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map2k5 基因产物(4)

mRNA Protein Name
NM_001364493.1 NP_001351422.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 3
NM_001364494.1 NP_001351423.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 4
NM_001364492.1 NP_001351421.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 2
NM_011840.3 NP_035970.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MAP kinase kinase activity IDA
IDA: 通过直接分析推断
19654213 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12912994 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within MAPK cascade IMP
IMP: 通过突变表型推断
15601854 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
15601854 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
19654213 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in spindle IDA
IDA: 通过直接分析推断
15509711 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Map2k5 蛋白结构

PB1_Map2k5

PB1_Map2k5: cd06395 (16 - 106)

PKc_MKK5

PKc_MKK5: cd06619 (163 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 448 a.a.
蛋白主名 其他名称

dual specificity mitogen-activated protein kinase kinase 5

MAP kinase kinase 5

MAPK/ERK kinase 5

Map2k5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Map2k5 Q9WVS7 Map3k2 Mus musculus Q61083
Pull Down
12912994
种属内
Map2k5 Q9WVS7 Map3k2 Mus musculus Q61083
CoIP
12912994
种属内
Map2k5 Q9WVS7 Map3k3 Mus musculus Q61084
CoIP
12912994
种属内
Map2k5 Q9WVS7 Map3k3 Mus musculus Q61084
Y2H
15102471
种属内
Map2k5 Q9WVS7 Map3k3 Mus musculus Q61084
Pull Down
12912994
种属内
Map2k5 Q9WVS7 Sqstm1 Mus musculus Q64337
Y2H
15102471
种属内
Map2k5 Q9WVS7 Nap1l1 Mus musculus P28656
Y2H
15102471
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map2k5 NCBI NCBI:5607