2. Gene
  3. Sqstm1 - sequestosome 1 Gene

Sqstm1 - sequestosome 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Osi; p62; A170; STAP; OSF-6; STONE14

基因 ID: 18412 | 基因类型: protein coding

关于 Sqstm1

功能概要

Enables K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including brown fat cell proliferation; energy homeostasis; and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome; autolysosome; and sperm midpiece. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Apr 2022]

Sqstm1 基因产物(2)

mRNA Protein Name
NM_001290769.1 NP_001277698.1 sequestosome-1 isoform 2
NM_011018.3 NP_035148.1 sequestosome-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: 通过直接分析推断
16252010 MGI
enables identical protein binding IDA
IDA: 通过直接分析推断
21220506 MGI
enables ionotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
19004011 MGI
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
33397898 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15102471 MGI
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
33397898 MGI
enables ubiquitin-modified protein reader activity IDA
IDA: 通过直接分析推断
25723488 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aggrephagy IDA
IDA: 通过直接分析推断
25723488 MGI
involved in autophagy IDA
IDA: 通过直接分析推断
20173742 MGI
involved in brown fat cell proliferation IMP
IMP: 通过突变表型推断
32385399 MGI
involved in energy homeostasis IMP
IMP: 通过突变表型推断
32385399 MGI
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
20173742 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24035364 MGI
involved in non-membrane-bounded organelle assembly IDA
IDA: 通过直接分析推断
33397898 MGI
involved in positive regulation of long-term synaptic potentiation IMP
IMP: 通过突变表型推断
19004011 MGI
involved in positive regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
19004011 MGI
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
32385399 MGI
involved in protein import into nucleus IMP
IMP: 通过突变表型推断
32385399 MGI
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
32385399 MGI
involved in temperature homeostasis IMP
IMP: 通过突变表型推断
32385399 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24035364 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in aggresome IDA
IDA: 通过直接分析推断
22792322 MGI
located in autolysosome IDA
IDA: 通过直接分析推断
26284655 MGI
located in autophagosome IDA
IDA: 通过直接分析推断
24713655 MGI
is active in intracellular non-membrane-bounded organelle IDA
IDA: 通过直接分析推断
33397898 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
32047033 MGI
located in phagophore assembly site IDA
IDA: 通过直接分析推断
21220506 MGI
located in sperm midpiece IDA
IDA: 通过直接分析推断
22033522 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sequestosome-1

oxidative stress induced

ubiquitin-binding protein p62

Sqstm1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Sqstm1 Q64337 MAP1LC3B Homo sapiens Q9GZQ8
Anti Tag CoIP
19250911
种属内
Sqstm1 Q64337 Keap1 Mus musculus Q9Z2X8
Pull Down
20173742
种属内
Sqstm1 Q64337 Keap1 Mus musculus Q9Z2X8
Anti Tag CoIP
20173742
种属间
Sqstm1 Q64337 KEAP1 Homo sapiens Q14145
Anti Tag CoIP
20173742
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112698 CA-5f 99.14% 否
HY-117469 Triptohypol C 95.44% 否
HY-152100 CUR5g Inhibitor 98.69% 否
HY-RS13745 SQSTM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-169385 ATC-324 Degrader / 否
HY-169386 YT 6-2 analog-1 Control / 否
HY-169387 YT 6-2-PEG3-C2-NH2 Control / 否
HY-169388 YT 6-2 Control / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sqstm1 NCBI NCBI:8878
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z