2. Gene
  3. Keap1 - kelch-like ECH-associated protein 1 Gene

Keap1 - kelch-like ECH-associated protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：kelch样ECH相关蛋白1

种属: Mus musculus

同用名: INRF2; mKIAA0132

基因 ID: 50868 | 基因类型: protein coding

关于 Keap1

Chromosome 9: 21,141,026-21,150,657 reverse strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 189 orthologues, 54 paralogues and is associated with 11 phenotypes. Ubiquitous expression in ovary adult (RPKM 41.2), adrenal adult (RPKM 36.) and 28 other tissues.

功能概要

实现无序域特异性结合活性和相同的蛋白质结合活性。参与细胞蛋白质代谢过程；细胞对氧化应激的反应；和自噬的调节。作用于多个过程的上游或内部，包括细胞对 interleukin-4 的反应；子宫内胚胎发育；和调节表皮细胞分化。位于肌动蛋白丝中；内质网；和包涵体。 Cul3-RING 泛素连接酶复合物的一部分。在眼和肢体间充质中表达。该基因的人类直系同源物与胆囊癌有关。与人类 KEAP1 同源（kelch 样 ECH 相关蛋白 1）。 [由基因组资源联盟提供，2022 年 4 月]

Enables disordered domain specific binding activity and identical protein binding activity. Involved in cellular protein metabolic process; cellular response to oxidative stress; and regulation of Autophagy. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin Ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder Cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Keap1 基因产物(4)

mRNA Protein Name
NM_016679.4 NP_057888.1 kelch-like ECH-associated protein 1
NM_001110306.1 NP_001103776.1 kelch-like ECH-associated protein 1
NM_001110305.1 NP_001103775.1 kelch-like ECH-associated protein 1
NM_001110307.1 NP_001103777.1 kelch-like ECH-associated protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables disordered domain specific binding IPI
IPI: 通过物理相互作用推断
16581765 MGI
enables identical protein binding IMP
IMP: 通过突变表型推断
16581765 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20133743 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12151510 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to interleukin-4 IDA
IDA: 通过直接分析推断
9798653 MGI
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
15282312 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
15087497 MGI
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
15282312 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
15087497 MGI
involved in regulation of autophagy IDA
IDA: 通过直接分析推断
20173742 MGI
acts upstream of or within regulation of epidermal cell differentiation IMP
IMP: 通过突变表型推断
15087497 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
15282312 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul3-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
15282312 MGI
located in actin filament IDA
IDA: 通过直接分析推断
14764898 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
15367669 MGI
located in cytoplasm IPI
IPI: 通过物理相互作用推断
14517290 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
14517290 MGI
located in inclusion body IDA
IDA: 通过直接分析推断
20173742 MGI
part of protein-containing complex IMP
IMP: 通过突变表型推断
16581765 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Keap1 蛋白结构

BTB_POZ_KLHL19_KEAP1

BTB_POZ_KLHL19_KEAP1: cd18248 (55 - 179)

PHA03098

PHA03098: cl33709 (94 - 595)

Kelch

Kelch: sd00038 (361 - 408)

Kelch

Kelch: sd00038 (412 - 455)

Kelch

Kelch: sd00038 (459 - 502)

Kelch

Kelch: sd00038 (506 - 550)

Kelch

Kelch: sd00038 (553 - 596)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 624 a.a.
蛋白主名 其他名称

kelch-like ECH-associated protein 1

NRF2 cytosolic inhibitor

cytosolic inhibitor of Nrf2

ring canal protein

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-N0005 Curcumin 98.84% Phase 4
HY-13755 Sulforaphane 99.75% Phase 4
Pre-clinical Phase
生物活性分子 (68)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100218A RSL3 99.90% 否
HY-112675 4-Octyl itaconate Activator 99.98% 否
HY-19543 Brusatol 99.89% 否
HY-101140 KI696 Inhibitor 99.26% 否
HY-110258 ML334 Activator 99.76% 否
HY-134205A CBR-470-1 Activator 98.03% 否
HY-111126 K67 Activator 98.43% 否
HY-145879 Nrf2 activator-2 Activator 98.92% 否
HY-13755A (R)-Sulforaphane 99.48% 否
HY-120371 CPUY192018 Inhibitor 98.99% 否
HY-W009731 Dibenzoylmethane Activator ≥98.0% 否
HY-110275 RA839 98.90% 否
HY-131592 Tricetin 99.19% 否
HY-139047 SW157765 Inhibitor 98.67% 否
HY-149508 Nrf2-IN-3 Inhibitor 99.19% 否
HY-B0854 Mancozeb / 否
HY-101140A KI696 isomer Inhibitor 99.32% 否
HY-P1328 TAT-14 Activator 99.66% 否
HY-100218C (1R,3R)-RSL3 99.52% 否
HY-122054A BPK-29 hydrochloride Inhibitor 98.28% 否
HY-149010 NXPZ-2 Inhibitor 98.18% 否
HY-150579 Keap1-Nrf2-IN-13 Inhibitor 96.77% 否
HY-110258B (R,S,R)-ML334 98.57% 否
HY-139620A MS83 epimer 1 98.36% 否
HY-122054 BPK-29 Inhibitor 99.4% 否
HY-121523 MIND4-17 Activator 99.93% 否
HY-139620 MS83 Chemical / 否
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% 否
HY-151362 Keap1-Nrf2-IN-14 Inhibitor / 否
HY-162152 biKEAP1 Inhibitor / 否
HY-RS07230 KEAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-112675S 4-Octyl itaconate-13C5-1 / 否
HY-124834 Nrf2 activator-10 / 否
HY-124941 7-Deacetylgedunin Activator / 否
HY-139862 Keap1-Nrf2-IN-3 Inhibitor / 否
HY-141439 TBE 31 Activator / 否
HY-143892 Keap1-Nrf2-IN-5 Inhibitor / 否
HY-143893 Keap1-Nrf2-IN-6 Inhibitor / 否
HY-144099 Keap1-Nrf2-IN-4 / 否
HY-146577 Keap1-Nrf2-IN-7 Inhibitor / 否
HY-146578 Keap1-Nrf2-IN-8 Inhibitor / 否
HY-147548 Keap1-Nrf2-IN-10 Inducer / 否
HY-147924 Keap1-Nrf2-IN-11 Inhibitor / 否
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / 否
HY-150578 Keap1-Nrf2-IN-12 Inhibitor / 否
HY-155997 Anti-inflammatory agent 56 Inhibitor / 否
HY-156065 S217879 Activator / 否
HY-157928 Keap1-Nrf2-IN-18 Inhibitor / 否
HY-157929 Keap1-Nrf2-IN-19 Inhibitor / 否
HY-159495 Keap1-Nrf2-IN-21 / 否
HY-160876 BC-1901S Activator / 否
HY-161643 S21-1011 / 否
HY-168065 Keap1-Nrf2-IN-22 Inhibitor / 否
HY-168161 Keap1-Nrf2-IN-23 Inhibitor / 否
HY-168526 Keap1-Nrf2-IN-24 Inhibitor / 否
HY-168640 RIP3 activator 1 / 否
HY-169315 Nrf2 activator 17 Activator / 否
HY-N10313 Dehydrobruceine B / 否
HY-N8160 Dehydrocurdione / 否
HY-P10530 Nrf2 (69-84) / 否
HY-P1328A TAT-14 TFA Activator / 否
HY-P5480 Keap1-Nrf2-IN-16 / 否
HY-P5909 Keap1-Nrf2 probe / 否
HY-P5909F FITC-labelled Keap1-Nrf2 probe / 否
HY-RS07231 Keap1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07232 Keap1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-162096 Keap1-Nrf2-IN-17 Inhibitor / 否
HY-W505984 TPNA10168 Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Keap1 NCBI NCBI:9817
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