2. Gene
  3. Keap1 - kelch-like ECH-associated protein 1 Gene

Keap1 - kelch-like ECH-associated protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：kelch样ECH相关蛋白1

种属: Mus musculus

同用名: INRF2; mKIAA0132

基因 ID: 50868 | 基因类型: protein coding

关于 Keap1

Chromosome 9: 21,141,026-21,150,657 reverse strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 189 orthologues, 54 paralogues and is associated with 11 phenotypes. Ubiquitous expression in ovary adult (RPKM 41.2), adrenal adult (RPKM 36.) and 28 other tissues.

功能概要

实现无序域特异性结合活性和相同的蛋白质结合活性。参与细胞蛋白质代谢过程；细胞对氧化应激的反应；和自噬的调节。作用于多个过程的上游或内部，包括细胞对 interleukin-4 的反应；子宫内胚胎发育；和调节表皮细胞分化。位于肌动蛋白丝中；内质网；和包涵体。 Cul3-RING 泛素连接酶复合物的一部分。在眼和肢体间充质中表达。该基因的人类直系同源物与胆囊癌有关。与人类 KEAP1 同源（kelch 样 ECH 相关蛋白 1）。 [由基因组资源联盟提供，2022 年 4 月]

Enables disordered domain specific binding activity and identical protein binding activity. Involved in cellular protein metabolic process; cellular response to oxidative stress; and regulation of Autophagy. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin Ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder Cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Keap1 基因产物(4)

mRNA Protein Name
NM_016679.4 NP_057888.1 kelch-like ECH-associated protein 1
NM_001110306.1 NP_001103776.1 kelch-like ECH-associated protein 1
NM_001110305.1 NP_001103775.1 kelch-like ECH-associated protein 1
NM_001110307.1 NP_001103777.1 kelch-like ECH-associated protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables disordered domain specific binding IPI
IPI: 通过物理相互作用推断
16581765 MGI
enables identical protein binding IMP
IMP: 通过突变表型推断
16581765 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20133743 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12151510 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to interleukin-4 IDA
IDA: 通过直接分析推断
9798653 MGI
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
15282312 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
15087497 MGI
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
15282312 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
15087497 MGI
involved in regulation of autophagy IDA
IDA: 通过直接分析推断
20173742 MGI
acts upstream of or within regulation of epidermal cell differentiation IMP
IMP: 通过突变表型推断
15087497 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
15282312 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul3-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
15282312 MGI
located in actin filament IDA
IDA: 通过直接分析推断
14764898 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
15367669 MGI
located in cytoplasm IPI
IPI: 通过物理相互作用推断
14517290 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
14517290 MGI
located in inclusion body IDA
IDA: 通过直接分析推断
20173742 MGI
part of protein-containing complex IMP
IMP: 通过突变表型推断
16581765 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Keap1 蛋白结构

BTB_POZ_KLHL19_KEAP1

BTB_POZ_KLHL19_KEAP1: cd18248 (55 - 179)

PHA03098

PHA03098: cl33709 (94 - 595)

Kelch

Kelch: sd00038 (361 - 408)

Kelch

Kelch: sd00038 (412 - 455)

Kelch

Kelch: sd00038 (459 - 502)

Kelch

Kelch: sd00038 (506 - 550)

Kelch

Kelch: sd00038 (553 - 596)

  • 0
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  • 400
  • 500
  • 624 a.a.
蛋白主名 其他名称

kelch-like ECH-associated protein 1

NRF2 cytosolic inhibitor

cytosolic inhibitor of Nrf2

ring canal protein

Keap1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Keap1 Q9Z2X8 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
20173742
种属内
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
ITC
24366543
种属内
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
X-Ray Diffraction
24366543
种属内
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
Pull Down
31169361
种属内
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
Pull Down
24366543
种属内
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
TSA
24366543
种属内
Keap1 Q9Z2X8 Nfe2l2 Mus musculus Q60795
SPR
24366543
种属内
Keap1 Q9Z2X8 Sqstm1 Mus musculus Q64337
X-Ray Diffraction
20173742
种属内
Keap1 Q9Z2X8 Sqstm1 Mus musculus Q64337
ITC
20173742
种属内
Keap1 Q9Z2X8 Sqstm1 Mus musculus Q64337
Anti Tag CoIP
20173742
种属内
Keap1 Q9Z2X8 Sqstm1 Mus musculus Q64337
Pull Down
20173742
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-N0005 Curcumin 98.84% Phase 4
HY-13755 Sulforaphane 99.75% Phase 4
Pre-clinical Phase
生物活性分子 (70)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100218A RSL3 99.90% 否
HY-112675 4-Octyl itaconate Activator 99.98% 否
HY-19543 Brusatol 99.89% 否
HY-101140 KI696 Inhibitor 99.26% 否
HY-110258 ML334 Activator 99.76% 否
HY-134205A CBR-470-1 Activator 98.03% 否
HY-111126 K67 Activator 98.43% 否
HY-145879 Nrf2 activator-2 Activator 98.92% 否
HY-120371 CPUY192018 Inhibitor 98.99% 否
HY-13755A (R)-Sulforaphane 99.48% 否
HY-W009731 Dibenzoylmethane Activator ≥98.0% 否
HY-110275 RA839 98.54% 否
HY-131592 Tricetin 99.19% 否
HY-149508 Nrf2-IN-3 99.19% 否
HY-B0854 Mancozeb / 否
HY-139047 SW157765 Inhibitor 98.67% 否
HY-101140A KI696 isomer Inhibitor 99.32% 否
HY-149010 NXPZ-2 Inhibitor 98.18% 否
HY-100218C (1R,3R)-RSL3 Control 99.52% 否
HY-P1328 TAT-14 Activator 99.66% 否
HY-122054A BPK-29 hydrochloride Inhibitor 98.28% 否
HY-150579 Keap1-Nrf2-IN-13 Inhibitor 96.77% 否
HY-110258B (R,S,R)-ML334 Control 98.57% 否
HY-139620A MS83 epimer 1 98.36% 否
HY-122054 BPK-29 Inhibitor 99.4% 否
HY-121523 MIND4-17 Activator 99.93% 否
HY-139620 MS83 Chemical / 否
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% 否
HY-151362 Keap1-Nrf2-IN-14 Inhibitor / 否
HY-162152 biKEAP1 Inhibitor / 否
HY-RS07230 KEAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-112675S 4-Octyl itaconate-13C5-1 / 否
HY-124834 Nrf2 activator-10 / 否
HY-124941 7-Deacetylgedunin Activator / 否
HY-139862 Keap1-Nrf2-IN-3 Inhibitor / 否
HY-141439 TBE 31 Activator / 否
HY-143892 Keap1-Nrf2-IN-5 Inhibitor / 否
HY-143893 Keap1-Nrf2-IN-6 Inhibitor / 否
HY-144099 Keap1-Nrf2-IN-4 / 否
HY-146577 Keap1-Nrf2-IN-7 Inhibitor / 否
HY-146578 Keap1-Nrf2-IN-8 Inhibitor / 否
HY-147924 Keap1-Nrf2-IN-11 Inhibitor / 否
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / 否
HY-150578 Keap1-Nrf2-IN-12 Inhibitor / 否
HY-155997 Anti-inflammatory agent 56 Inhibitor / 否
HY-156065 S217879 Activator / 否
HY-157928 Keap1-Nrf2-IN-18 Inhibitor / 否
HY-157929 Keap1-Nrf2-IN-19 Inhibitor / 否
HY-159495 Keap1-Nrf2-IN-21 / 否
HY-160876 BC-1901S Activator / 否
HY-161643 S21-1011 / 否
HY-168065 Keap1-Nrf2-IN-22 Inhibitor / 否
HY-168161 Keap1-Nrf2-IN-23 Inhibitor / 否
HY-168526 Keap1-Nrf2-IN-24 Inhibitor / 否
HY-168640 RIP3 activator 1 / 否
HY-168709 Nrf2 activator 18 Activator / 否
HY-169315 Nrf2 activator 17 Activator / 否
HY-171035 PRL-295 Inhibitor / 否
HY-N10313 Dehydrobruceine B / 否
HY-N8160 Dehydrocurdione / 否
HY-P10530 Nrf2 (69-84) / 否
HY-P1328A TAT-14 TFA Activator / 否
HY-P5480 Keap1-Nrf2-IN-16 / 否
HY-P5909 Keap1-Nrf2 probe / 否
HY-P5909F FITC-labelled Keap1-Nrf2 probe / 否
HY-RS07231 Keap1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07232 Keap1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-147548 Keap1-Nrf2-IN-10 Inhibitor / 否
HY-162096 Keap1-Nrf2-IN-17 Inhibitor / 否
HY-W505984 TPNA10168 Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Keap1 NCBI NCBI:9817
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