2. Gene
  3. Nfe2l2 - nuclear factor, erythroid derived 2, like 2 Gene

Nfe2l2 - nuclear factor, erythroid derived 2, like 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：核因子，红细胞衍生 2 ，like 2

种属: Mus musculus

同用名: Nrf2

基因 ID: 18024 | 基因类型: protein coding

关于 Nfe2l2

Chromosome 2: 75,505,857-75,534,985 reverse strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 218 orthologues, 3 paralogues and is associated with 92 phenotypes. Ubiquitous expression in bladder adult (RPKM 57.1), duodenum adult (RPKM 26.8) and 26 other tissues.

功能概要

该基因编码的转录因子是碱性亮氨酸拉链 (bZIP) 蛋白小家族的成员。编码的转录因子调节启动子中含有抗氧化反应元件 (ARE) 的基因；这些基因中有许多编码的蛋白质参与对损伤和炎症的反应，包括自由基的产生。 [RefSeq 提供，2015 年 9 月]

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. [provided by RefSeq, Sep 2015]

Nfe2l2 基因产物(2)

mRNA Protein Name
NM_001399226.1 NP_001386155.1 nuclear factor erythroid 2-related factor 2 isoform 2
NM_010902.5 NP_035032.1 nuclear factor erythroid 2-related factor 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12220541 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10037736 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
9240432 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10037736 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9240432 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
9240432 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
9240432 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
17920186 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in PERK-mediated unfolded protein response IDA
IDA: 通过直接分析推断
14517290 MGI
involved in cell redox homeostasis IMP
IMP: 通过突变表型推断
14978030 MGI
acts upstream of or within cellular response to copper ion IMP
IMP: 通过突变表型推断
24462598 MGI
involved in cellular response to glucose starvation IMP
IMP: 通过突变表型推断
14978030 MGI
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
9240432 MGI
acts upstream of or within cellular response to oxidative stress IMP
IMP: 通过突变表型推断
20978266 MGI
acts upstream of or within cellular response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
24486487 MGI
acts upstream of or within endoplasmic reticulum unfolded protein response IDA
IDA: 通过直接分析推断
14517290 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
24486487 MGI
involved in negative regulation of hematopoietic stem cell differentiation IMP
IMP: 通过突变表型推断
23434824 MGI
involved in positive regulation of D-glucose import IDA
IDA: 通过直接分析推断
24024172 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14517290 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: 通过遗传相互作用推断
15087497 MGI
involved in positive regulation of blood coagulation IMP
IMP: 通过突变表型推断
20978343 MGI
involved in positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
14978030 MGI
involved in positive regulation of glutathione biosynthetic process IMP
IMP: 通过突变表型推断
14978030 MGI
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
20978343 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10037736 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24462598 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
14978030 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
24866179 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12220541 MGI
acts upstream of or within regulation of embryonic development IGI
IGI: 通过遗传相互作用推断
15087497 MGI
involved in regulation of innate immune response IMP
IMP: 通过突变表型推断
16585964 MGI
involved in regulation of removal of superoxide radicals IMP
IMP: 通过突变表型推断
20978343 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
14978030 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
20978343 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
14978030 MGI
located in cytoplasm IPI
IPI: 通过物理相互作用推断
14517290 MGI
located in cytosol IDA
IDA: 通过直接分析推断
23043106 MGI
located in nucleus IDA
IDA: 通过直接分析推断
14517290 MGI
part of protein-DNA complex IDA
IDA: 通过直接分析推断
14517290 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nfe2l2 蛋白结构

bZIP_NFE2-like

bZIP_NFE2-like: cd14720 (485 - 552)

bZIP_NFE2-like

bZIP_NFE2-like: cd14720 (486 - 548)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 597 a.a.
蛋白主名 其他名称

nuclear factor erythroid 2-related factor 2

NF-E2-related factor 2

NFE2-related factor 2

Nfe2l2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Nfe2l2 Q60795 Keap1 Mus musculus Q9Z2X8
IF
38556546
种属内
Nfe2l2 Q60795 Keap1 Mus musculus Q9Z2X8
Anti Bait CoIP
38556546
种属内
Nfe2l2 Q60795 Keap1 Mus musculus Q9Z2X8
Pull Down
24366543
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12213 CDDO-EA Activator 99.71% 否
HY-145390 Nrf2 activator-1 Activator 95.74% 否
HY-RS09245 NFE2L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09246 Nfe2l2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09247 Nfe2l2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nfe2l2 NCBI NCBI:4780
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