2. Anti-infection NF-κB Apoptosis Metabolic Enzyme/Protease
  3. Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450
  4. Mancozeb

Mancozeb  (Synonyms: 代森锰锌)

目录号: HY-B0854
COA 产品使用指南

摩尔计算器

Mancozeb 为广泛使用的杀菌剂，能有效地防治大多数谷物、蔬菜、水果和观赏植物的真菌病害。此外，Mancozeb 在小鼠中能通过激活 Keap1/Nrf2 信号通路导致肝损伤。Mancozeb 可上调乳酸脱氢酶和细胞色素 c 来改变细胞代谢和诱导细胞死亡。Mancozeb 具有生殖毒性，可诱导卵巢细胞凋亡 (apoptosis)。

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Mancozeb Chemical Structure

Mancozeb Chemical Structure

CAS No. : 8018-01-7

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Customer Review

Other Forms of Mancozeb:

Mancozeb 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells[1][2][3][4].

体外研究
(In Vitro)

Mancozeb (0.1-500 ppm；24-48 小时) 对 HepG2 细胞有较大的毒性，会影响细胞代谢，诱导细胞损伤[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mancozeb 相关抗体:

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 0.1, 1, 10, 100 and 500 ppm;
1, 10 and 100 ppm
Incubation Time: 24 h;
48 h
Result: Was toxic to cells at all concentrations.
Reduced cell viability (to below 50%) at 24 h, resulted in total cell death with a 48-hour exposure to 100ppm.

Western Blot Analysis[2]

Cell Line: HepG2 cells
Concentration: 0.1, 1, 10 and 100 ppm
Incubation Time: 24 h and 48 h
Result: Reduced the levels of LDH and cytochrome c.
体内研究
(In Vivo)

Mancozeb (0-300 mg/kg；口服；30 天) 在小鼠中通过激活 Keap1/Nrf2 信号通路导致肝损伤，但可被 Glycyrrhiza polysaccharides 缓解[3]。
Mancozeb (100 mg/kg；灌胃；30 天) 会导致小鼠致卵巢损伤和细胞凋亡[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Kunming mice aged 6 weeks old[3]
Dosage: 0, 50, 100, 150, 200, 250 and 300 mg/kg
Administration: Oral administration (p.o.); 30 days
Result: Reduced body weight in mice in a concentration-dependent manner.
Significantly reduced the liver organ index of mice at doses of 250 mg/kg and 300 mg/kg.
Reduced the levels of CAT, SOD and ROS in a concentration-dependent manner.
Significantly up-regulated the levels of Keap1 and Nrf2 in the liver.
Animal Model: Kunming mice aged 6 weeks old[4]
Dosage: 100 mg/kg
Administration: Oral gavage (i.g.); 30 days
Result: Reduced body weight in mice.
Destroyed the ovary structure of mice and decreased the levels of follicle stimulating hormone and luteinizing hormone.
Caused mitochondrial oxidative phosphorylation dysfunction and oxidative stress.
Activated the Bax/Bcl-2 pathway and caspase family, thereby inducing apoptosis.
分子量

661.36

Formula

C8H12Mn2N4S8Zn22-
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

代森锰锌
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 1 mg/mL (1.51 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5120 mL 7.5602 mL 15.1204 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Mancozeb 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5120 mL 7.5602 mL 15.1204 mL 37.8009 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mancozeb8018-01-7代森锰锌FungalKeap1-Nrf2ApoptosisLactate DehydrogenaseCytochrome P450LDHCYPsFungicideOvarian cellsHepG2 cellsLiver injuryInhibitorinhibitorinhibit

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