Malt1 - MALT1 paracaspase Gene

中文名称：MALT1 副半胱天冬酶

种属: Mus musculus

同用名: Pcasp1; A630046N12; D430033E09Rik

基因 ID: 240354 | 基因类型: protein coding

关于 Malt1

Chromosome 18: 65,564,009-65,612,138 forward strand.GRCm39:CM001011.3

This gene has 13 transcripts (splice variants), 197 orthologues and is associated with 14 phenotypes. Ubiquitous expression in spleen adult (RPKM 11.3), mammary gland adult (RPKM 4.9) and 27 other tissues.

功能概要

该基因编码的蛋白可启动蛋白酶结合活性。参与脂多糖介导的信号通路；免疫反应的正向调节；和蛋白水解。作用于多个过程的上游或内部，包括 B-1 B 细胞分化；细胞对脂多糖的反应；和 NF-kappaB 转录因子活性的正调控。位于胞质溶胶中。圆点的一部分。在神经系统和神经视网膜中表达。该基因与免疫缺陷 12 相关的人类直向同源基因；淋巴瘤;和非霍奇金淋巴瘤。与人 MALT1（MALT1 副半胱天冬酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protease binding activity. Involved in lipopolysaccharide-mediated signaling pathway; positive regulation of immune response; and proteolysis. Acts upstream of or within several processes, including B-1 B cell differentiation; cellular response to lipopolysaccharide; and positive regulation of NF-kappaB transcription factor activity. Located in cytosol. Part of polkadots. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in immunodeficiency 12; lymphoma; and non-Hodgkin lymphoma. Orthologous to human MALT1 (MALT1 paracaspase). [provided by Alliance of Genome Resources, Apr 2022]

Malt1 基因产物(2)

mRNA	Protein	Name
NM_001365019.1	NP_001351948.1	mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 2
NM_172833.3	NP_766421.1	mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protease binding	IPI IPI: 通过物理相互作用推断	18223652	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	16495340	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within B cell activation	IMP IMP: 通过突变表型推断	14576442	MGI
acts upstream of or within B-1 B cell differentiation	IMP IMP: 通过突变表型推断	14614861	MGI
acts upstream of or within T cell proliferation	IMP IMP: 通过突变表型推断	14576442	MGI
involved in T cell receptor signaling pathway	IDA IDA: 通过直接分析推断	25282160	MGI
involved in cellular response to lipopolysaccharide	IEP IEP: 通过表达模式推断	16831874	MGI
involved in innate immune response	IEP IEP: 通过表达模式推断	16831874	MGI
involved in lipopolysaccharide-mediated signaling pathway	IDA IDA: 通过直接分析推断	16831874	MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	14614861	MGI
acts upstream of or within positive regulation of T cell activation	IMP IMP: 通过突变表型推断	14614861	MGI
involved in positive regulation of T-helper 17 cell differentiation	IDA IDA: 通过直接分析推断	25282160	MGI
involved in proteolysis	IDA IDA: 通过直接分析推断	25282160	MGI
acts upstream of or within regulation of T cell receptor signaling pathway	IMP IMP: 通过突变表型推断	14614861	MGI
acts upstream of or within response to fungus	IMP IMP: 通过突变表型推断	16862125	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	16831874	MGI
part of polkadots	IDA IDA: 通过直接分析推断	16495340	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Malt1 蛋白结构

Death_MALT1

Ig_3

Peptidase_C14

MALT1_Ig

0
200
400
600
821 a.a.

蛋白主名

其他名称

mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog

mucosa associated lymphoid tissue lymphoma translocation gene 1

paracaspase-1

相关产品

Clinical Phase

生物活性分子 (2)

目录号	产品名	作用方式	纯度	Phase
HY-139399	Safimaltib	Inhibitor	99.63%	Phase 1
HY-160698	SGR-1505	Inhibitor	99.89%	Phase 1

Pre-clinical Phase

生物活性分子 (27)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12276	MALT1 inhibitor MI-2	Inhibitor	99.95%	否
HY-115466	MLT-748	Inhibitor	99.89%	否
HY-121282	Mepazine	Inhibitor	99.91%	否
HY-121282A	Mepazine hydrochloride	Inhibitor	99.94%	否
HY-134820	MLT-943	Inhibitor	99.77%	否
HY-142648	MLT-985	Inhibitor	99.34%	否
HY-P1407	Z-VRPR-FMK TFA	Inhibitor	95.92%	否
HY-131902	MLT-231	Inhibitor	99.55%	否
HY-124587	MLT-747	Inhibitor	99.56%	否
HY-150232	MALT1-IN-11	Inhibitor	/	否
HY-143427	MALT1-IN-9	Inhibitor	/	否
HY-162268	MALT1-IN-13	Inhibitor	/	否
HY-143424	MALT1-IN-6	Inhibitor	/	否
HY-148249	NVS-MALT1	Inhibitor	/	否
HY-120231	Z-VRPR-FMK	Inhibitor	/	否
HY-143425	MALT1-IN-7	Inhibitor	/	否
HY-143422	MALT1-IN-3	Inhibitor	/	否
HY-151805	RGT-068A	Inhibitor	/	否
HY-P4544	Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone	Inhibitor	/	否
HY-121282B	Mepazine acetate	Inhibitor	/	否
HY-143422A	(R)-MALT1-IN-3	Inhibitor	/	否
HY-143423	MALT1-IN-5	Inhibitor	/	否
HY-164560	MALT1-IN-14	Inhibitor	/	否
HY-142648A	(R)-MLT-985	Inhibitor	/	否
HY-143423A	(S)-MALT1-IN-5	Inhibitor	/	否
HY-143425A	(R)-MALT1-IN-7	Inhibitor	/	否
HY-143426	MALT1-IN-8	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Malt1	NCBI	NCBI:10892

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