ALDH1A1 - aldehyde dehydrogenase 1 family, member A1 Gene

中文名称：醛脱氢酶 1 家族，成员A1

种属: Rattus norvegicus

同用名: Ahd2; Aldh1; Aldh2

基因 ID: 24188 | 基因类型: protein coding

关于 ALDH1A1

Primary_assembly 1: 218,042,127-218,152,961 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 200 orthologues, 20 paralogues and is associated with 53 phenotypes. Biased expression in Kidney (RPKM 2289.1), Testes (RPKM 1535.4) and 6 other tissues.

功能概要

该基因编码的蛋白可启动苯甲醛脱氢酶 (NAD+) 活性；相同的蛋白质结合活性；和视网膜脱氢酶活性。参与多个过程，包括发情周期；保持晶状体透明度；和维甲酸代谢过程。位于细胞质和细胞核中。与人类 ALDH1A1（醛脱氢酶 1 家族成员 A1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables benzaldehyde dehydrogenase (NAD+) activity; identical protein binding activity; and retinal dehydrogenase activity. Involved in several processes, including estrous cycle; maintenance of lens transparency; and retinoic acid metabolic process. Located in cytoplasm and nucleus. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

ALDH1A1 基因产物(1)

mRNA	Protein	Name
NM_022407.3	NP_071852.2	aldehyde dehydrogenase 1A1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables aldehyde dehydrogenase (NAD+) activity	IDA IDA: 通过直接分析推断	10998257	RGD
enables aldehyde dehydrogenase (NAD+) activity	IMP IMP: 通过突变表型推断	15623782	RGD
enables benzaldehyde dehydrogenase (NAD+) activity	IDA IDA: 通过直接分析推断	10998257	RGD
enables identical protein binding	IPI IPI: 通过物理相互作用推断	10998257	RGD
enables retinal dehydrogenase activity	IDA IDA: 通过直接分析推断	7832787	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 9-cis-retinoic acid metabolic process	IDA IDA: 通过直接分析推断	17167544	RGD
involved in cellular detoxification of aldehyde	IMP IMP: 通过突变表型推断	15623782	RGD
involved in estrous cycle	IEP IEP: 通过表达模式推断	18202528	RGD
involved in kidney development	IEP IEP: 通过表达模式推断	15567713	RGD
involved in liver development	IEP IEP: 通过表达模式推断	14729401	RGD
involved in maintenance of lens transparency	IMP IMP: 通过突变表型推断	15623782	RGD
involved in midgut development	IEP IEP: 通过表达模式推断	15964596	RGD
involved in response to estradiol	IEP IEP: 通过表达模式推断	18202528	RGD
involved in response to ethanol	IDA IDA: 通过直接分析推断	17673211	RGD
involved in response to organic cyclic compound	IEP IEP: 通过表达模式推断	18807137	RGD
involved in response to oxidative stress	IMP IMP: 通过突变表型推断	15623782	RGD
involved in response to retinoic acid	IEP IEP: 通过表达模式推断	11169459	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	10323328	RGD
involved in retinoic acid biosynthetic process	IMP IMP: 通过突变表型推断	21138835	RGD
involved in retinoid metabolic process	IDA IDA: 通过直接分析推断	7832787	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ALDH1A1 蛋白结构

ALDH_F1AB_F2_RALDH1

0
100
200
300
400
520 a.a.

蛋白主名

其他名称

aldehyde dehydrogenase 1A1

retinal dehydrogenase 1

3-deoxyglucosone dehydrogenase	ALDH-E1
ALHDII	RALDH 1
aldehyde dehydrogenase 1, subfamily A1	aldehyde dehydrogenase 2
aldehyde dehydrogenase family 1 member A1	aldehyde dehydrogenase family 1, subfamily A1
aldehyde dehydrogenase, cytosolic	ralDH1

相关产品

Pre-clinical Phase

生物活性分子 (26)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-138097	α-NETA		≥98.0%	否
HY-18768	NCT-501	Inhibitor	99.84%	否
HY-148466	IGUANA-1	Inhibitor	98.88%	否
HY-112278	NCT-506	Inhibitor	99.95%	否
HY-135841	CM010	Inhibitor	98.07%	否
HY-123621	GNE-375	Inhibitor	99.81%	否
HY-112277	NCT-505	Inhibitor	98.41%	否
HY-146683	KS106		99.31%	否
HY-110294	CM037	Inhibitor	99.06%	否
HY-146682	KS100		99.61%	否
HY-126003	ALDH1A1-IN-2	Inhibitor	99.31%	否
HY-122912	ALDH1A inhibitor 673A		98.81%	否
HY-148243	IGUANA-1 free base	Inhibitor	99.69%	否
HY-157567	FSI-TN42	Inhibitor	98.05%	否
HY-125085	ALDH3A1-IN-3	Inhibitor	99.30%	否
HY-146240	ALDH1A1-IN-3	Inhibitor	/	否
HY-155816	PROTAC NSD3 degrader-1		/	否
HY-157872	ALDH1A1-IN-4	Inhibitor	/	否
HY-158026	ALDH1A1-IN-5	Inhibitor	/	否
HY-159111	KS124		/	否
HY-18768A	NCT-501 hydrochloride	Inhibitor	/	否
HY-RS00560	ALDH1A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00561	Aldh1a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00562	ALDH1A1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00565	ALDH1B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS00566	ALDH1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	ALDH1A1	NCBI	NCBI:216

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