Pde5a - phosphodiesterase 5A, cGMP-specific Gene

中文名称：磷酸二酯酶 5A，cGMP 特异性

种属: Mus musculus

同用名: Cn5n; Pde5; Cgbpde; PDE5a2; Pde5a1

关于 Pde5a

功能概要

该基因编码的蛋白可启动 3',5'-环状核苷酸磷酸二酯酶活性和 cGMP 结合活性。参与 MAP 激酶活性的正向调节；调节肌肉系统过程；和放松心肌。作用于多个过程的上游或内部，包括 cGMP 分解代谢过程； T 细胞增殖的负调节；和卵母细胞发育的正调节。预测位于胞质溶胶中。以多种结构表达，包括消化系统；脑;泌尿生殖系统；呼吸系统;和感觉器官。该基因的人类直系同源物与 IgA 肾小球肾炎有关。与人 PDE5A（磷酸二酯酶 5A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Involved in positive regulation of MAP kinase activity; regulation of muscle system process; and relaxation of cardiac muscle. Acts upstream of or within several processes, including cGMP catabolic process; negative regulation of T cell proliferation; and positive regulation of oocyte development. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A). [provided by Alliance of Genome Resources, Apr 2022]