Edn1 - endothelin 1 Gene

中文名称：内皮素1

种属: Rattus norvegicus

同用名: Et1

关于 Edn1

功能概要

该基因编码的蛋白可启动内皮素 A 受体结合活性和内皮素 B 受体结合活性。参与多个过程，包括细胞对细胞因子刺激的反应；细胞分泌调节；和对皮质类固醇的反应。位于多个细胞成分中，包括 Weibel-Palade 体；细胞基部；和粗面内质网腔。用于研究成人呼吸窘迫综合征；冠状动脉疾病;膜增生性肾小球肾炎;代谢性酸中毒;和门静脉高压症。多种疾病的生物标志物，包括动脉疾病（多种）；心脏病（多种）；肾功能衰竭（多发）；肺部疾病（多发）；和肾炎（多发）。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；支气管疾病（多发）；肥胖;阻塞性睡眠呼吸暂停;和类风湿性关节炎。与人类 EDN1（内皮素 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables endothelin A receptor binding activity and endothelin B receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; regulation of secretion by cell; and response to corticosteroid. Located in several cellular components, including Weibel-Palade body; basal part of cell; and rough endoplasmic reticulum lumen. Used to study adult respiratory distress syndrome; coronary artery disease; membranoproliferative glomerulonephritis; metabolic acidosis; and portal hypertension. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); kidney failure (multiple); lung disease (multiple); and nephritis (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1). [provided by Alliance of Genome Resources, Apr 2022]