2. Gene
  3. Grm1 - glutamate metabotropic receptor 1 Gene

Grm1 - glutamate metabotropic receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：谷氨酸代谢型受体 1

种属: Rattus norvegicus

同用名: Gprc1a

基因 ID: 24414 | 基因类型: protein coding

关于 Grm1

Primary_assembly 1: 5,058,292-5,453,170 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 285 orthologues, 7 paralogues and is associated with 15 phenotypes. Restricted expression toward (RPKM 9.5).

功能概要

使 G 蛋白偶联受体活性参与调节突触后膜电位和雌激素受体结合活性。参与多个过程，包括G蛋白偶联谷氨酸受体信号通路；钙介导的信号；和调节谷氨酸能突触传递。位于轴突；树突棘;和突触膜。在谷氨酸能突触中活跃。是突触后密度膜的组成部分。颞叶癫痫的生物标志物。该基因的人类直系同源基因与常染色体隐性遗传脊髓小脑性共济失调 13 和脊髓小脑性共济失调 44 相关。与人类 GRM1（谷氨酸代谢受体 1）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential and Estrogen Receptor binding activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; calcium-mediated signaling; and regulation of glutamatergic synaptic transmission. Located in axon; dendritic spine; and synaptic membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Grm1 基因产物(2)

mRNA Protein Name
NM_017011.2 NP_058707.2 metabotropic glutamate receptor 1 isoform alpha precursor
NM_001114330.2 NP_001107802.1 metabotropic glutamate receptor 1 isoform beta precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear estrogen receptor binding IPI
IPI: 通过物理相互作用推断
18948402 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9069287 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium-mediated signaling IDA
IDA: 通过直接分析推断
15229243 RGD
involved in chemical synaptic transmission IEP
IEP: 通过表达模式推断
12514201 RGD
involved in regulation of synaptic transmission, glutamatergic IDA
IDA: 通过直接分析推断
11530226 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
11530226 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
18582438 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
8104433 RGD
located in neuron projection IDA
IDA: 通过直接分析推断
15829628 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15829628 RGD
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
8104433 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
8104433 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
11530226 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Grm1 蛋白结构

PBP1_mGluR_groupI

PBP1_mGluR_groupI: cd06374 (35 - 509)

NCD3G

NCD3G: pfam07562 (520 - 570)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (590 - 615)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (590 - 839)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (627 - 648)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (657 - 681)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (705 - 725)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (748 - 774)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (782 - 805)

7tmC_mGluR1

7tmC_mGluR1: cd15449 (808 - 833)

GluR_Homer-bdg

GluR_Homer-bdg: pfam10606 (1148 - 1198)

  • 0
  • 200
  • 400
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  • 1000
  • 1199 a.a.
蛋白主名 其他名称

metabotropic glutamate receptor 1

G protein coupled receptor family C group 1 member A

glutamate receptor, metabotropic 1

mGluR1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05819 GRM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05820 Grm1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05821 Grm1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grm1 NCBI NCBI:2911
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