Nras - NRAS proto-oncogene, GTPase Gene

中文名称：NRAS 原癌基因，GTP 酶

种属: Rattus norvegicus

关于 Nras

功能概要

预测该基因编码的蛋白可启动 GDP 绑定活动； GTP结合活性；和 GTPase 活性。预计参与Ras蛋白信号转导；血管生成的正向调节；和内皮细胞增殖的正调节。预测作用于多个过程的上游或内部，包括 T 细胞受体信号通路；对原生动物的防御反应；和干扰素-γ 产生的正向调节。预测位于高尔基体和膜上。预计在质膜上有活性。该基因的人类直系同源物与多种疾病有关，包括努南综合征 6；自身免疫性淋巴增生综合征 4 型；内分泌腺癌（多发）；血液系统癌症（多发性）；和生殖器官癌（多发性）。与人类 NRAS（NRAS 原癌基因，GTPase）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to act upstream of or within several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland Cancer (multiple); hematologic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]