2. Gene
  3. Pklr - pyruvate kinase L/R Gene

Pklr - pyruvate kinase L/R Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: PK1; PKL; Pklg

基因 ID: 24651 | 基因类型: protein coding

关于 Pklr

功能概要

Enables Pyruvate Kinase activity. Involved in several processes, including cellular response to organonitrogen compound; pyruvate metabolic process; and response to purine-containing compound. Located in cytosol. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; Pyruvate Kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (Pyruvate Kinase L/R). [provided by Alliance of Genome Resources, Apr 2022]

Pklr 基因产物(1)

mRNA Protein Name
NM_012624.3 NP_036756.3 pyruvate kinase PKLR
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables monosaccharide binding IPI
IPI: 通过物理相互作用推断
6742850 RGD
enables pyruvate kinase activity IDA
IDA: 通过直接分析推断
1834654 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to epinephrine stimulus IEP
IEP: 通过表达模式推断
10620345 RGD
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
9395079 RGD
involved in glycolytic process IDA
IDA: 通过直接分析推断
4273555 RGD
involved in pyruvate biosynthetic process IDA
IDA: 通过直接分析推断
4273555 RGD
involved in response to ATP IDA
IDA: 通过直接分析推断
11104754 RGD
involved in response to cAMP IDA
IDA: 通过直接分析推断
9395079 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
16644726 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
11356723 RGD
involved in response to metal ion IEP
IEP: 通过表达模式推断
11357483 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
11368649 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pyruvate kinase PKLR

L-PK

pyruvate kinase isozymes L/R

pyruvate kinase isozymes R/L

pyruvate kinase, liver and RBC

pyruvate kinase, liver and red blood cell

重组 Pklr 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700578 PKLR Protein, Rat (P. pastoris, His) P12928 (M1-S574) ≥95%

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12689 Mitapivat Activator 99.83% 是
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122682 SBI-993 98.67% 否
HY-135884 Tebapivat Activator 99.66% 否
HY-12689B Mitapivat hemisulfate Activator / 否
HY-RS10601 PKLR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-12689A Mitapivat hemisulfate sesquihydrate Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pklr NCBI NCBI:5313
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