2. Gene
  3. Slc2a1 - solute carrier family 2 member 1 Gene

Slc2a1 - solute carrier family 2 member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 2 成员 1

种属: Rattus norvegicus

同用名: GTG1; Gtg3; GLUTB; Glut1; RATGTG1

基因 ID: 24778 | 基因类型: protein coding

关于 Slc2a1

Primary_assembly 5: 132,717,196-132,745,416 forward strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 374 orthologues, 12 paralogues and is associated with 52 phenotypes. Biased expression in Brain (RPKM 185.1), Kidney (RPKM 121.2) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 D-葡萄糖跨膜转运蛋白活性；脱氢抗坏血酸跨膜转运蛋白活性；和激酶结合活性。参与多个过程，包括细胞高渗反应；细胞对机械刺激的反应；和脱氢抗坏血酸运输。位于多个细胞成分中，包括 Z 盘；基底外侧质膜；和插盘。与肌膜共定位。高血压的生物标志物；甲状腺功能减退症;和大脑中动脉梗塞。该基因的人类直系同源物与脑部疾病有关（多个）；碳水化合物代谢紊乱；脊髓脊膜膨出；肥胖;和 2 型糖尿病。与人类 SLC2A1（溶质载体家族 2 成员 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and kinase binding activity. Involved in several processes, including cellular hyperosmotic response; cellular response to mechanical stimulus; and dehydroascorbic acid transport. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Colocalizes with sarcolemma. Biomarker of hypertension; hypothyroidism; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder; myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc2a1 基因产物(1)

mRNA Protein Name
NM_138827.2 NP_620182.1 solute carrier family 2, facilitated glucose transporter member 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D-glucose transmembrane transporter activity IDA
IDA: 通过直接分析推断
2211693 RGD
enables dehydroascorbic acid transmembrane transporter activity IDA
IDA: 通过直接分析推断
18668520 RGD
enables kinase binding IPI
IPI: 通过物理相互作用推断
16419038 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10562431 RGD
enables xenobiotic transmembrane transporter activity IDA
IDA: 通过直接分析推断
17064664 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-glucose import IMP
IMP: 通过突变表型推断
31709908 RGD
involved in D-glucose transmembrane transport IDA
IDA: 通过直接分析推断
2211693 RGD
involved in cellular hyperosmotic response IEP
IEP: 通过表达模式推断
11546675 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19918242 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
16581179 RGD
involved in dehydroascorbic acid transport IDA
IDA: 通过直接分析推断
9228080 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
21744335 RGD
involved in response to Thyroglobulin triiodothyronine IEP
IEP: 通过表达模式推断
16581179 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
29676955 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
12399425 RGD
involved in xenobiotic transport IDA
IDA: 通过直接分析推断
17064664 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
8214053 RGD
located in apical plasma membrane IDA
IDA: 通过直接分析推断
18619525 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
18619525 RGD
located in caveola IDA
IDA: 通过直接分析推断
16419038 RGD
located in cell-cell junction IDA
IDA: 通过直接分析推断
17090404 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
18668520 RGD
located in intercalated disc IDA
IDA: 通过直接分析推断
8214053 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
18668520 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
8214053 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Slc2a1 蛋白结构

MFS_GLUT_Class1

MFS_GLUT_Class1: cd17431 (13 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 492 a.a.
蛋白主名 其他名称

solute carrier family 2, facilitated glucose transporter member 1

GLUT-1

Solute carrier family 2 a 1 (facilitated glucose transporter) brain

glucose transporter type 1, erythrocyte/brain

solute carrier family 2 (facilitated glucose transporter), member 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13157 SLC2A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13158 Slc2a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13159 Slc2a1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc2a1 NCBI NCBI:6513
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