2. Gene
  3. Tbxa2r - thromboxane A2 receptor Gene

Tbxa2r - thromboxane A2 receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：血栓素 A2 受体

种属: Rattus norvegicus

基因 ID: 24816 | 基因类型: protein coding

关于 Tbxa2r

Primary_assembly 7: 8,383,378-8,388,176 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 193 orthologues, 8 paralogues and is associated with 22 phenotypes. Biased expression in Thymus (RPKM 14.9), Lung (RPKM 32.5) and 7 other tissues.

功能概要

该基因编码的蛋白可启动血栓素受体活性。参与多个过程，包括细胞对脂多糖的反应；血管收缩的正向调节；和对睾丸激素的反应。位于顶体小泡和质膜。用于研究成人呼吸窘迫综合征；肾功能衰竭;血小板减少症;和中毒性休克综合症。该基因的人类直系同源物与阿司匹林引起的呼吸系统疾病有关；哮喘;和血小板疾病。与人类 TBXA2R（血栓素 A2 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables thromboxane receptor activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of vasoconstriction; and response to testosterone. Located in acrosomal vesicle and plasma membrane. Used to study adult respiratory distress syndrome; kidney failure; thrombocytopenia; and toxic shock syndrome. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease; asthma; and blood platelet disease. Orthologous to human TBXA2R (thromboxane A2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Tbxa2r 基因产物(1)

mRNA Protein Name
NM_017054.2 NP_058750.2 thromboxane A2 receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20959415 RGD
enables thromboxane receptor activity IDA
IDA: 通过直接分析推断
7635958 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
10513923 RGD
involved in positive regulation of angiogenesis IDA
IDA: 通过直接分析推断
16720756 RGD
involved in positive regulation of blood coagulation IMP
IMP: 通过突变表型推断
7848332 RGD
involved in positive regulation of blood pressure IMP
IMP: 通过突变表型推断
16115588 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
7635958 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
10513923 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
9262373 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
14621185 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
8092292 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
11409645 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in acrosomal vesicle IDA
IDA: 通过直接分析推断
7649122 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tbxa2r 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (24 - 316)

7tm_GPCRs

7tm_GPCRs: cd14964 (26 - 50)

7tm_GPCRs

7tm_GPCRs: cd14964 (62 - 84)

7tm_GPCRs

7tm_GPCRs: cd14964 (104 - 126)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (190 - 213)

7tm_GPCRs

7tm_GPCRs: cd14964 (240 - 262)

7tm_GPCRs

7tm_GPCRs: cd14964 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
蛋白主名 其他名称

thromboxane A2 receptor

TXA2-R

TXR2

Thromboxane receptor

prostanoid TP receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14283 TBXA2R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14284 Tbxa2r Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14285 Tbxa2r Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tbxa2r NCBI NCBI:6915
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