2. Gene
  3. Slc6a3 - solute carrier family 6 member 3 Gene

Slc6a3 - solute carrier family 6 member 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 6 成员 3

种属: Rattus norvegicus

同用名: Dat1

基因 ID: 24898 | 基因类型: protein coding

关于 Slc6a3

Primary_assembly 1: 29,709,443-29,750,413 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 166 orthologues, 20 paralogues and is associated with 31 phenotypes. Biased expression in Brain (RPKM 15.2), Kidney (RPKM .8) and 1 other tissue.

功能概要

该基因编码的蛋白可启动多种功能，包括胺结合活性；多巴胺：钠同向转运体活性；和酶结合活性。参与多个过程，包括多巴胺转运；对 cAMP 的反应；和对乙醇的反应。位于神经元投射和质膜。在多巴胺能突触中活跃。是突触后膜的组成部分和突触前膜的组成部分。帕金森症的生物标志物；海洛因依赖；高级别神经胶质瘤；高催乳素血症;和高血压。该基因的人类直系同源物与注意力缺陷多动障碍有关；尼古丁依赖；和肥胖。与人类 SLC6A3（溶质载体家族 6 成员 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including amine binding activity; dopamine:sodium symporter activity; and Enzyme binding activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a3 基因产物(1)

mRNA Protein Name
NM_012694.2 NP_036826.1 sodium-dependent dopamine transporter
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amine binding IDA
IDA: 通过直接分析推断
15763134 RGD
enables amine binding IPI
IPI: 通过物理相互作用推断
15763134 RGD
enables dopamine:sodium symporter activity IDA
IDA: 通过直接分析推断
1765147 RGD
enables dopamine:sodium symporter activity IMP
IMP: 通过突变表型推断
1502198 RGD
enables heterocyclic compound binding IPI
IPI: 通过物理相互作用推断
15763134 RGD
enables norepinephrine:sodium symporter activity IDA
IDA: 通过直接分析推断
8125921 RGD
enables protease binding IPI
IPI: 通过物理相互作用推断
19419578 RGD
enables protein phosphatase 2A binding IPI
IPI: 通过物理相互作用推断
20035724 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
15056723 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
18256931 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dopamine transport IDA
IDA: 通过直接分析推断
1765147 RGD
involved in response to cAMP IDA
IDA: 通过直接分析推断
15234104 RGD
involved in response to ethanol IDA
IDA: 通过直接分析推断
15897718 RGD
involved in response to iron ion IEP
IEP: 通过表达模式推断
12672939 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
15157990 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
12541010 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
15992364 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in dopaminergic synapse IDA
IDA: 通过直接分析推断
8551328 RGD
located in neuron projection IDA
IDA: 通过直接分析推断
32963038 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
21399631 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
8551328 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
8551328 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Slc6a3 蛋白结构

SLC6sbd_DAT1

SLC6sbd_DAT1: cd11514 (59 - 612)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
蛋白主名 其他名称

sodium-dependent dopamine transporter

DA transporter

DAT

solute carrier family 6 (neurotransmitter transporter), member 3

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13308 SLC6A3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13309 Slc6a3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13310 Slc6a3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc6a3 NCBI NCBI:6531
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