2. Gene
  3. Tacr2 - tachykinin receptor 2 Gene

Tacr2 - tachykinin receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：速激肽受体 2

种属: Rattus norvegicus

同用名: Tac2r

基因 ID: 25007 | 基因类型: protein coding

关于 Tacr2

Primary_assembly 20: 30,208,907-30,223,446 forward strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 200 orthologues, 50 paralogues and is associated with 6 phenotypes. Biased expression in Adrenal (RPKM 43.), Uterus (RPKM 5.5) and 1 other tissue.

功能概要

该基因编码的蛋白可启动物质 K 受体活性。涉及多个过程，包括操作性条件反射；子宫平滑肌收缩的正调节；和细胞分泌的调节。位于膜内。用于研究结肠炎和肺动脉高压。结肠炎的生物标志物。该基因的人类直系同源物与哮喘有关。与人 TACR2（速激肽受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables substance K receptor activity. Involved in several processes, including operant conditioning; positive regulation of uterine smooth muscle contraction; and regulation of secretion by cell. Located in membrane. Used to study colitis and pulmonary hypertension. Biomarker of colitis. Human ortholog(s) of this gene implicated in asthma. Orthologous to human TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tacr2 基因产物(1)

mRNA Protein Name
NM_080768.1 NP_542946.1 substance-K receptor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables substance K receptor activity IDA
IDA: 通过直接分析推断
1662278 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intestine smooth muscle contraction IMP
IMP: 通过突变表型推断
11275010 RGD
involved in negative regulation of luteinizing hormone secretion IMP
IMP: 通过突变表型推断
9376629 RGD
involved in operant conditioning IMP
IMP: 通过突变表型推断
17324063 RGD
involved in positive regulation of acetylcholine secretion, neurotransmission IMP
IMP: 通过突变表型推断
12747940 RGD
involved in positive regulation of monoatomic ion transport IMP
IMP: 通过突变表型推断
11275010 RGD
involved in positive regulation of uterine smooth muscle contraction IDA
IDA: 通过直接分析推断
12390879 RGD
involved in positive regulation of vascular permeability IMP
IMP: 通过突变表型推断
9374705 RGD
involved in prolactin secretion IMP
IMP: 通过突变表型推断
9376629 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
18440496 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tacr2 蛋白结构

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (33 - 317)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (34 - 60)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (67 - 93)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (105 - 135)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (146 - 167)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (193 - 222)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (242 - 272)

7tmA_SKR_NK2R

7tmA_SKR_NK2R: cd16004 (285 - 310)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
蛋白主名 其他名称

substance-K receptor

NK-2 receptor

NK-2R

SKR

Tachykinin 2 (substance K) receptor

neurokinin A receptor

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P3848 Tyr0-Neurokinin A Agonist / 否
HY-RS14146 TACR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14147 Tacr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14148 Tacr2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tacr2 NCBI NCBI:6865
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