2. Gene
  3. Casp1 - caspase 1 Gene

Casp1 - caspase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：半胱天冬酶 1

种属: Rattus norvegicus

同用名: Ice; p45; Il1bc

基因 ID: 25166 | 基因类型: protein coding

关于 Casp1

Primary_assembly 8: 2,587,831-2,597,383 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 456 orthologues, 12 paralogues and is associated with 40 phenotypes. Biased expression in Spleen (RPKM 365.4), Lung (RPKM 223.6) and 8 other tissues.

功能概要

该基因编码的蛋白可启动支架蛋白结合活性。参与多个过程，包括成肌细胞融合；昼夜节律睡眠/觉醒周期的正向调节，非快速眼动睡眠；和 IL-1 β 产生的正向调节。位于细胞质中；神经元投射；和核。部分含蛋白质复合物。用于研究急性肾功能衰竭和视觉性癫痫。与人类 CASP1（caspase 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables scaffold protein binding activity. Involved in several processes, including myoblast fusion; positive regulation of circadian sleep/wake cycle, non-REM sleep; and positive regulation of interleukin-1 beta production. Located in cytoplasm; neuron projection; and nucleus. Part of protein-containing complex. Used to study acute kidney failure and visual epilepsy. Orthologous to human CASP1 (Caspase 1). [provided by Alliance of Genome Resources, Apr 2022]

Casp1 基因产物(1)

mRNA Protein Name
NM_012762.3 NP_036894.3 caspase-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18367607 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
19416975 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lung development IEP
IEP: 通过表达模式推断
12396474 RGD
involved in memory IMP
IMP: 通过突变表型推断
16197515 RGD
involved in microglial cell activation IMP
IMP: 通过突变表型推断
15149850 RGD
involved in midgut development IEP
IEP: 通过表达模式推断
12396474 RGD
involved in myoblast fusion IMP
IMP: 通过突变表型推断
12832042 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
15663890 RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: 通过突变表型推断
16455762 RGD
involved in positive regulation of cytokine production IMP
IMP: 通过突变表型推断
17384935 RGD
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
16942597 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
12829320 RGD
involved in response to lipopolysaccharide IMP
IMP: 通过突变表型推断
17384935 RGD
involved in response to organic cyclic compound IDA
IDA: 通过直接分析推断
17561093 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
20638366 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
16165281 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
19416975 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Casp1 蛋白结构

CARD_CASP1-like

CARD_CASP1-like: cd08325 (5 - 86)

CASc

CASc: smart00115 (151 - 399)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
蛋白主名 其他名称

caspase-1

IL-1 beta-converting enzyme

Interleukin 1beta converting enzyme

interleukin 1, beta, convertase

interleukin-1 beta-converting enzyme

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150536 EP39 Inhibitor / 否
HY-RS01941 CASP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01942 Casp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01943 Casp1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Casp1 NCBI NCBI:834
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