2. Gene
  3. Drd5 - dopamine receptor D5 Gene

Drd5 - dopamine receptor D5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：多巴胺受体 D5

种属: Rattus norvegicus

同用名: D1B

基因 ID: 25195 | 基因类型: protein coding

关于 Drd5

Primary_assembly 14: 72,489,347-72,490,774 reverse strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 190 orthologues, 35 paralogues and is associated with 12 phenotypes.

功能概要

该基因编码的蛋白可启动 G 蛋白 α 亚基结合活性和多巴胺神经递质受体活性。参与多个过程，包括腺苷酸环化酶激活多巴胺受体信号通路；蛋白激酶活性的负调节；和视觉学习。作用于腺苷酸环化酶激活 G 蛋白偶联受体信号通路的上游或内部。位于多种细胞成分中，包括刷状缘膜；树突棘;和神经细胞体。在谷氨酸能突触中活跃。是突触后密度膜的组成部分。该基因的人类直系同源物与注意缺陷多动障碍和眼睑痉挛有关。与人类 DRD5（多巴胺受体 D5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G-protein alpha-subunit binding activity and dopamine neurotransmitter receptor activity. Involved in several processes, including adenylate cyclase-activating Dopamine Receptor signaling pathway; negative regulation of protein kinase activity; and visual learning. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including brush border membrane; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and blepharospasm. Orthologous to human DRD5 (Dopamine Receptor D5). [provided by Alliance of Genome Resources, Apr 2022]

Drd5 基因产物(1)

mRNA Protein Name
NM_012768.2 NP_036900.2 D(1B) dopamine receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G-protein alpha-subunit binding IPI
IPI: 通过物理相互作用推断
12623966 RGD
enables dopamine neurotransmitter receptor activity IDA
IDA: 通过直接分析推断
1831904 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19465068 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled dopamine receptor signaling pathway IDA
IDA: 通过直接分析推断
1831904 RGD
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
1831904 RGD
involved in adenylate cyclase-activating dopamine receptor signaling pathway IMP
IMP: 通过突变表型推断
12688394 RGD
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
12688394 RGD
involved in negative regulation of protein kinase activity IMP
IMP: 通过突变表型推断
12688394 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels EXP
EXP: 通过实验结果推断
16914681 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: 通过直接分析推断
16914681 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: 通过表达模式推断
16914681 RGD
involved in visual learning IMP
IMP: 通过突变表型推断
17142305 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
16175554 RGD
located in brush border membrane IDA
IDA: 通过直接分析推断
12623966 RGD
located in dendrite IDA
IDA: 通过直接分析推断
16175554 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
21749912 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
16914681 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16914681 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
21749912 RGD
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
21749912 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

D(1B) dopamine receptor

d(5) dopamine receptor

dopamine D5 receptor

dopamine receptor 5

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04006 DRD5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04007 Drd5 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04008 Drd5 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Drd5 NCBI NCBI:1816
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