2. Gene
  3. Cnr1 - cannabinoid receptor 1 Gene

Cnr1 - cannabinoid receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：大麻素受体 1

种属: Rattus norvegicus

同用名: SKR6R

基因 ID: 25248 | 基因类型: protein coding

关于 Cnr1

Primary_assembly 5: 48,408,574-48,435,099 forward strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 206 orthologues, 18 paralogues and is associated with 57 phenotypes. Biased expression in Brain (RPKM 374.6), Adrenal (RPKM 99.1) and 2 other tissues.

功能概要

该基因编码的蛋白可启动大麻素受体活性。参与多个过程，包括急性炎症反应的正调节；细胞分泌调节；和对生物碱的反应。位于膜筏和质膜。与细胞内膜结合的细胞器共定位。用于研究多种疾病，包括帕金森病；糖尿病性神经病变；阳痿;肥胖;和消化性溃疡病。癫痫持续状态的生物标志物。该基因的人类直系同源物与肥胖有关；精神分裂症;和 2 型糖尿病。与人类 CNR1（大麻素受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Cannabinoid Receptor activity. Involved in several processes, including positive regulation of acute inflammatory response; regulation of secretion by cell; and response to alkaloid. Located in membrane raft and plasma membrane. Colocalizes with intracellular membrane-bounded organelle. Used to study several diseases, including Parkinsonism; diabetic neuropathy; impotence; obesity; and peptic ulcer disease. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (Cannabinoid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Cnr1 基因产物(1)

mRNA Protein Name
NM_012784.5 NP_036916.1 cannabinoid receptor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cannabinoid receptor activity IMP
IMP: 通过突变表型推断
2165569 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17356572 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
2165569 RGD
involved in cannabinoid signaling pathway IDA
IDA: 通过直接分析推断
17895407 RGD
involved in learning or memory IMP
IMP: 通过突变表型推断
19880592 RGD
involved in maternal process involved in female pregnancy IEP
IEP: 通过表达模式推断
19860893 RGD
involved in memory IDA
IDA: 通过直接分析推断
19666083 RGD
involved in negative regulation of action potential IMP
IMP: 通过突变表型推断
20067581 RGD
involved in negative regulation of blood pressure IMP
IMP: 通过突变表型推断
19295473 RGD
involved in negative regulation of dopamine secretion IMP
IMP: 通过突变表型推断
19187091 RGD
involved in negative regulation of fatty acid beta-oxidation IMP
IMP: 通过突变表型推断
19724020 RGD
involved in negative regulation of mast cell activation IDA
IDA: 通过直接分析推断
18552882 RGD
involved in negative regulation of monoatomic ion transport IDA
IDA: 通过直接分析推断
19463903 RGD
involved in negative regulation of nitric-oxide synthase activity IMP
IMP: 通过突变表型推断
18561998 RGD
involved in negative regulation of serotonin secretion IMP
IMP: 通过突变表型推断
30217553 RGD
involved in positive regulation of acute inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
19282305 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
19560819 RGD
involved in positive regulation of blood pressure IMP
IMP: 通过突变表型推断
19553924 RGD
involved in positive regulation of fever generation IMP
IMP: 通过突变表型推断
19681872 RGD
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
19861414 RGD
involved in regulation of feeding behavior IMP
IMP: 通过突变表型推断
19575185 RGD
involved in regulation of insulin secretion IMP
IMP: 通过突变表型推断
19644453 RGD
involved in regulation of lipid metabolic process IMP
IMP: 通过突变表型推断
19325539 RGD
involved in regulation of penile erection IMP
IMP: 通过突变表型推断
17850365 RGD
involved in regulation of synaptic transmission, GABAergic IMP
IMP: 通过突变表型推断
19725112 RGD
involved in regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
19725112 RGD
involved in response to cocaine IMP
IMP: 通过突变表型推断
19401177 RGD
involved in response to ethanol IMP
IMP: 通过突变表型推断
19860799 RGD
involved in response to lipopolysaccharide IMP
IMP: 通过突变表型推断
19295473 RGD
involved in response to nicotine IMP
IMP: 通过突变表型推断
19463710 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
19807847 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
18614700 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane raft IDA
IDA: 通过直接分析推断
21895628 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
17895407 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cnr1 蛋白结构

7tmA_CB1

7tmA_CB1: cd15340 (117 - 408)

7tmA_CB1

7tmA_CB1: cd15340 (118 - 144)

7tmA_CB1

7tmA_CB1: cd15340 (152 - 177)

7tmA_CB1

7tmA_CB1: cd15340 (189 - 219)

7tmA_CB1

7tmA_CB1: cd15340 (231 - 251)

7tmA_CB1

7tmA_CB1: cd15340 (271 - 300)

7tmA_CB1

7tmA_CB1: cd15340 (336 - 366)

7tmA_CB1

7tmA_CB1: cd15340 (376 - 401)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
蛋白主名 其他名称

cannabinoid receptor 1

CB-R

CB1

brain-type cannabinoid receptor

cannabinoid receptor 1 (brain)

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02914 CNR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02915 Cnr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02916 Cnr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cnr1 NCBI NCBI:1268
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