2. Gene
  3. Gdnf - glial cell derived neurotrophic factor Gene

Gdnf - glial cell derived neurotrophic factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: gndf

基因 ID: 25453 | 基因类型: protein coding

关于 Gdnf

功能概要

Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and regulation of morphogenesis of an epithelium. Located in extracellular space. Part of receptor complex. Used to study Parkinsonism and middle cerebral artery infarction. Biomarker of Parkinsonism and sciatic neuropathy. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Gdnf 基因产物(2)

mRNA Protein Name
NM_001401780.1 NP_001388709.1 glial cell line-derived neurotrophic factor isoform 2
NM_019139.2 NP_062012.2 glial cell line-derived neurotrophic factor isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glial cell-derived neurotrophic factor receptor binding IPI
IPI: 通过物理相互作用推断
10545102 RGD
enables growth factor activity IDA
IDA: 通过直接分析推断
12595497 RGD
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
9187648 RGD
enables receptor ligand activity IMP
IMP: 通过突变表型推断
10545102 RGD
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
10545102 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to dexamethasone stimulus IDA
IDA: 通过直接分析推断
17537984 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
22111653 RGD
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis IDA
IDA: 通过直接分析推断
17522159 RGD
involved in midbrain development IEP
IEP: 通过表达模式推断
16650834 RGD
involved in negative regulation of glial cell apoptotic process IMP
IMP: 通过突变表型推断
22251670 RGD
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
32428552 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
21311297 RGD
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
32428552 RGD
involved in neuron differentiation IDA
IDA: 通过直接分析推断
15109990 RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis IDA
IDA: 通过直接分析推断
17522159 RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: 通过突变表型推断
17537984 RGD
involved in positive regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
32428552 RGD
involved in positive regulation of neuron differentiation IMP
IMP: 通过突变表型推断
21311297 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
10545102 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
32428552 RGD
involved in regulation of ureteric bud formation IDA
IDA: 通过直接分析推断
19112489 RGD
involved in retina development in camera-type eye IEP
IEP: 通过表达模式推断
16650834 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
12595497 RGD
located in extracellular space IMP
IMP: 通过突变表型推断
10545102 RGD
part of receptor complex IDA
IDA: 通过直接分析推断
15709767 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glial cell line-derived neurotrophic factor

ATF

Glial cell line derived neutrophic factor

astrocyte-derived trophic factor

重组 Gdnf 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73075 GDNF Protein, Rat (sf9, His) Q07731-1 (S78-I211) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-124401 BT-13 Agonist 99.57% 否
HY-111969 BT18 99.77% 否
HY-119910 (E)-Aminoquinol 99.70% 否
HY-123439 FTY720-C2 / 否
HY-RS05361 GDNF Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-119910B Aminoquinol phosphate Agonist / 否
HY-119910C Aminoquinol triphosphate Agonist / 否
HY-W101298S (Leu-13C6,15N)-Ile-OH TFA / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gdnf NCBI NCBI:2668
Canis familiaris Gdnf NCBI NCBI:119871563
Mus musculus Gdnf NCBI NCBI:14573
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z