2. Gene
  3. LPCAT4 - lysophosphatidylcholine acyltransferase 4 Gene

LPCAT4 - lysophosphatidylcholine acyltransferase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶血磷脂酰胆碱酰基转移酶 4

种属: Homo sapiens

同用名: AYTL3; AGPAT7; LPEAT2; LPLAT10; LPAAT-eta

基因 ID: 254531 | 基因类型: protein coding

关于 LPCAT4

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:34,358,633-34,367,196 (from NCBI)

This gene has 9 transcripts (splice variants), 195 orthologues and 4 paralogues. Ubiquitous expression in stomach (RPKM 27.5), duodenum (RPKM 20.5) and 23 other tissues.

功能概要

1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) 家族的成员，如 AGPAT7，催化溶血磷脂酸 (LPA) 转化为磷脂酸 (PA) ，磷脂酸是所有甘油脂生物合成的前体。 LPA 和 PA 都参与信号转导 (Ye et al., 2005 [PubMed 16243729]) 。[OMIM 提供，2008 年 5 月]

Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]

LPCAT4 基因产物(1)

mRNA Protein Name
NM_153613.3 NP_705841.2 lysophospholipid acyltransferase LPCAT4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: 通过直接分析推断
18458083 GOA
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
IDA: 通过直接分析推断
18458083 GOA
enables 1-acylglycerophosphoserine O-acyltransferase activity IDA
IDA: 通过直接分析推断
18458083 GOA
enables 1-alkenylglycerophosphoethanolamine O-acyltransferase activity IDA
IDA: 通过直接分析推断
18458083 GOA
enables 1-alkylglycerophosphocholine O-acetyltransferase activity IDA
IDA: 通过直接分析推断
18458083 GOA
enables lysophospholipid acyltransferase activity IDA
IDA: 通过直接分析推断
18458083 GOA
enables lysophospholipid acyltransferase activity IMP
IMP: 通过突变表型推断
18458083 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phosphatidylcholine acyl-chain remodeling IDA
IDA: 通过直接分析推断
18458083 GOA
involved in phosphatidylethanolamine acyl-chain remodeling IDA
IDA: 通过直接分析推断
18458083 GOA
involved in phosphatidylserine acyl-chain remodeling IDA
IDA: 通过直接分析推断
18458083 GOA
acts upstream of or within phospholipid metabolic process IDA
IDA: 通过直接分析推断
18458083 GOA
acts upstream of or within phospholipid metabolic process IMP
IMP: 通过突变表型推断
18458083 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
18458083 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LPCAT4 蛋白结构

Acyltransferase

Acyltransferase: Acyltransferase (108 - 231)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 524 a.a.
蛋白主名 其他名称

lysophospholipid acyltransferase LPCAT4

1-AGP acyltransferase 7

关联疾病

疾病名称 别名
Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract

Pharc Syndrome

PHARC

Polyneyropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract

Polyneuropathy-Hearing Loss-Ataxia-Retinitis Pigmentosa-Cataract Syndrome

Peripheral Neuropathy, Fiskerstrand Type

Polyneuropathy-Deafness-Ataxia-Retinitis Pigmentosa-Cataract Syndrome

Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, Cataract
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07767 LPCAT4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LPCAT4 MGD MGI:2138993
Felis catus LPCAT4 VGNC VGNC:63267
Bos taurus LPCAT4 VGNC VGNC:30964
Canis familiaris LPCAT4 VGNC VGNC:54323
Macaca mulatta LPCAT4 VGNC VGNC:74402
Rattus norvegicus LPCAT4 RGD RGD:1311177
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z