Slc6a4 - solute carrier family 6 member 4 Gene

中文名称：溶质载体家族 6 成员 4

种属: Rattus norvegicus

同用名: SERT

关于 Slc6a4

功能概要

该基因编码的蛋白可启动多种功能，包括可卡因结合活动；血清素：钠同向转运体活性；和 syntaxin-1 结合活性。参与多个过程，包括细胞对 cGMP 的反应；细胞对视黄酸的反应；和多巴胺能突触传递的负调节。位于几种细胞成分中，包括膜筏；神经元投射；和突触。在血清素能突触中活跃。是突触后膜的组成部分和突触前膜的组成部分。用于研究焦虑症；精神抑郁症；和肺动脉高压。帕金森病和博尔纳病的生物标志物。该基因的人类直系同源基因与多种疾病有关，包括酒精使用障碍；述情障碍;焦虑症（多种）；心脏病（多种）；和精神抑郁症（多种）。与人类 SLC6A4（溶质载体家族 6 成员 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including cocaine binding activity; serotonin:sodium symporter activity; and syntaxin-1 binding activity. Involved in several processes, including cellular response to cGMP; cellular response to retinoic acid; and negative regulation of dopaminergic synaptic transmission. Located in several cellular components, including membrane raft; neuron projection; and synapse. Is active in serotonergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study anxiety disorder; mental depression; and pulmonary hypertension. Biomarker of Parkinsonism and borna disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Apr 2022]