1. Gene
  2. BCL6B - BCL6B transcription repressor Gene

BCL6B - BCL6B transcription repressor Gene

中文名称:BCL6B 转录抑制因子

种属: Homo sapiens

同用名: BAZF; ZNF62; ZBTB28

基因 ID: 255877 | 基因类型: protein coding

关于 BCL6B

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,023,050-7,029,644 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and 28 paralogues. Broad expression in fat (RPKM 17.2), lung (RPKM 14.1) and 22 other tissues.

功能概要

启用序列特异性双链 DNA 结合活性。预计参与多个过程,包括基因表达的调节;调节炎症反应;和 2 型免疫反应。预测位于核内。预计在核质中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including regulation of gene expression; regulation of inflammatory response; and type 2 immune response. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BCL6B 基因产物(1)

mRNA Protein Name
NM_181844.4 NP_862827.2 B-cell CLL/lymphoma 6 member B protein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

BCL6B 蛋白结构

BTB

BTB: BTB/POZ domain (28 - 134)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (342 - 366)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (370 - 394)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (398 - 423)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (427 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
蛋白主名 其他名称

B-cell CLL/lymphoma 6 member B protein

B cell CLL/lymphoma 6B

BCL6B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BCL6B Q8N143 SULT4A1 Homo sapiens Q9BR01
Anti Tag CoIP
33961781
种属内
BCL6B Q8N143 SULT4A1 Homo sapiens Q9BR01
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus BCL6B MGD MGI:1278332
Bos taurus BCL6B VGNC VGNC:57982
Rattus norvegicus BCL6B RGD RGD:1563179
Macaca mulatta BCL6B VGNC VGNC:70037
Canis familiaris BCL6B VGNC VGNC:58662