2. Gene
  3. Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：核受体亚家族 3 ，C 组，成员 2

种属: Rattus norvegicus

同用名: MCR; Mlr

基因 ID: 25672 | 基因类型: protein coding

关于 Nr3c2

Primary_assembly 19: 30,715,648-31,059,885 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 213 orthologues, 8 paralogues and is associated with 11 phenotypes. Biased expression in Kidney (RPKM 16.1), Heart (RPKM 15.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合活性；相同的蛋白质结合活性；和类固醇激素受体活性。参与细胞群增殖的调节。位于细胞质和细胞核中。在谷氨酸能突触中活跃；突触后密度，细胞内成分；和突触前活动区细胞质成分。该基因的人类直系同源物与常染色体显性假性醛固酮减少症 1 型和假性醛固酮减少症有关。与人 NR3C2（核受体亚家族 3 C 组成员 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA binding activity; identical protein binding activity; and steroid hormone receptor activity. Involved in regulation of cell population proliferation. Located in cytoplasm and nucleus. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c2 基因产物(2)

mRNA Protein Name
NM_013131.2 NP_037263.2 mineralocorticoid receptor
NM_001395077.1 NP_001382006.1 mineralocorticoid receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
8618925 RGD
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
8618925 RGD
enables histone acetyltransferase binding IPI
IPI: 通过物理相互作用推断
10847590 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
8618925 RGD
enables nuclear steroid receptor activity IMP
IMP: 通过突变表型推断
17260968 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12902338 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
8618925 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8618925 RGD
enables steroid binding IMP
IMP: 通过突变表型推断
17260968 RGD
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
10847590 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to aldosterone IEP
IEP: 通过表达模式推断
16087789 RGD
involved in cellular response to aldosterone IMP
IMP: 通过突变表型推断
10847590 RGD
involved in locomotory behavior IMP
IMP: 通过突变表型推断
30171933 RGD
involved in nuclear receptor-mediated corticosteroid signaling pathway IDA
IDA: 通过直接分析推断
10399770 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
10847590 RGD
involved in regulation of cell population proliferation IDA
IDA: 通过直接分析推断
16115202 RGD
involved in response to alcohol IEP
IEP: 通过表达模式推断
16925589 RGD
involved in response to corticosterone IDA
IDA: 通过直接分析推断
10399770 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16087789 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21179518 RGD
located in nucleus IDA
IDA: 通过直接分析推断
16087789 RGD
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
21179518 RGD
is active in presynaptic active zone cytoplasmic component IDA
IDA: 通过直接分析推断
21179518 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nr3c2 蛋白结构

NR_DBD_GR_PR

NR_DBD_GR_PR: cd07172 (599 - 677)

NR_LBD_MR

NR_LBD_MR: cd07075 (737 - 984)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 985 a.a.
蛋白主名 其他名称

mineralocorticoid receptor

MR

Mineralocorticoid receptor (aldosterone receptor)

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09547 NR3C2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09548 Nr3c2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09549 Nr3c2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nr3c2 NCBI NCBI:4306
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z