2. Gene
  3. Ppard - peroxisome proliferator-activated receptor delta Gene

Ppard - peroxisome proliferator-activated receptor delta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：过氧化物酶体增殖物激活受体 δ

种属: Rattus norvegicus

同用名: Pparb

基因 ID: 25682 | 基因类型: protein coding

关于 Ppard

Primary_assembly 20: 6,298,785-6,363,968 forward strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 421 orthologues, 19 paralogues and is associated with 19 phenotypes. Biased expression in Heart (RPKM 3.7), Adrenal (RPKM 23.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 NF-kappaB 结合活性和脂肪酸结合活性。涉及几个过程，包括蜕膜化；胶原生物合成过程的负调节；胰岛素分泌的正调节参与细胞对葡萄糖刺激的反应。位于核内。该基因的人类直系同源物与 2 型糖尿病有关。与人 PPARD（过氧化物酶体增殖物激活受体 delta）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NF-kappaB binding activity and fatty acid binding activity. Involved in several processes, including decidualization; negative regulation of collagen biosynthetic process; and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PPARD (peroxisome proliferator activated receptor delta). [provided by Alliance of Genome Resources, Apr 2022]

Ppard 基因产物(1)

mRNA Protein Name
NM_013141.2 NP_037273.2 peroxisome proliferator-activated receptor delta
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NF-kappaB binding IPI
IPI: 通过物理相互作用推断
15728586 RGD
enables fatty acid binding IDA
IDA: 通过直接分析推断
12600885 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
15728586 RGD
involved in decidualization IEP
IEP: 通过表达模式推断
12773104 RGD
involved in embryo implantation IEP
IEP: 通过表达模式推断
12773104 RGD
involved in fatty acid oxidation IDA
IDA: 通过直接分析推断
12600885 RGD
involved in heart development IEP
IEP: 通过表达模式推断
15754086 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
16337160 RGD
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
18293166 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
17346664 RGD
involved in negative regulation of smooth muscle cell migration IDA
IDA: 通过直接分析推断
18585719 RGD
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
18585719 RGD
involved in phospholipid biosynthetic process IDA
IDA: 通过直接分析推断
17148578 RGD
involved in positive regulation of epidermis development IDA
IDA: 通过直接分析推断
19675577 RGD
involved in positive regulation of fatty acid oxidation IMP
IMP: 通过突变表型推断
19965574 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IDA
IDA: 通过直接分析推断
19965574 RGD
involved in proteoglycan metabolic process IDA
IDA: 通过直接分析推断
17140817 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
20233940 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
18573863 RGD
involved in response to vitamin A IEP
IEP: 通过表达模式推断
19342198 RGD
involved in vasodilation IDA
IDA: 通过直接分析推断
19906781 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ppard 蛋白结构

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (71 - 154)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (171 - 438)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
蛋白主名 其他名称

peroxisome proliferator-activated receptor delta

peroxisome proliferator activator receptor beta

peroxisome proliferator activator receptor, delta

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-121579 L-764406 Agonist / 否
HY-RS10922 PPARD Human Pre-designed siRNA Set A / 否
HY-RS10923 Ppard Mouse Pre-designed siRNA Set A / 否
HY-RS10924 Ppard Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ppard NCBI NCBI:5467
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