2. Gene
  3. PLAT - Plat plasminogen activator, tissue type Gene

PLAT - Plat plasminogen activator, tissue type Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: tPA; PATISS

基因 ID: 25692 | 基因类型: protein coding

关于 PLAT

功能概要

Predicted to enable phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of ovulation; and prevention of polyspermy. Located in cytoplasm; extracellular space; and synapse. Is active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; Factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Orthologous to human PLAT (plasminogen activator, tissue type). [provided by Alliance of Genome Resources, Apr 2022]

PLAT 基因产物(1)

mRNA Protein Name
NM_013151.3 NP_037283.2 tissue-type plasminogen activator precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
3137452 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: 通过表达模式推断
3102470 RGD
involved in cellular response to luteinizing hormone stimulus IEP
IEP: 通过表达模式推断
3102470 RGD
involved in plasminogen activation IDA
IDA: 通过直接分析推断
8343497 RGD
involved in prevention of polyspermy IDA
IDA: 通过直接分析推断
1515147 RGD
involved in regulation of synaptic plasticity IEP
IEP: 通过表达模式推断
12070304 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
3017447 RGD
involved in response to fatty acid IEP
IEP: 通过表达模式推断
14614217 RGD
involved in synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
15496678 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
3102470 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16555239 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
16555239 RGD
is active in neuronal dense core vesicle IDA
IDA: 通过直接分析推断
21976424 RGD
is active in neuronal dense core vesicle IMP
IMP: 通过突变表型推断
21976424 RGD
is active in perisynaptic space IDA
IDA: 通过直接分析推断
16555239 RGD
is active in perisynaptic space IMP
IMP: 通过突变表型推断
16555239 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
15496678 RGD
is active in postsynapse IMP
IMP: 通过突变表型推断
16555239 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tissue-type plasminogen activator

t-PA

t-plasminogen activator

tissue plasminogen activator

tissue-type plasminogen activator-like

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10646 PLAT Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens PLAT NCBI NCBI:5327
Canis familiaris PLAT NCBI NCBI:482840
Macaca fascicularis PLAT NCBI NCBI:102145462
Mus musculus PLAT NCBI NCBI:18791
Macaca mulatta PLAT NCBI NCBI:704475
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