TMEM158 - transmembrane protein 158 Gene

中文名称：跨膜蛋白 158

种属: Homo sapiens

同用名: BBP; RIS1; p40BBP

关于 TMEM158

功能概要

Ras 通路的本构激活触发不可逆的增殖停滞，让人联想到复制衰老。该基因的转录响应于 Ras 通路的激活而上调，但在其他诱导衰老的条件下则不会。编码的蛋白质类似于在神经元存活通路中发挥作用的大鼠细胞表面受体。该基因中的等位基因多态性导致功能性和非功能性 (移码) 等位基因；参考基因组代表功能等位基因。[RefSeq 提供，2015 年 7 月]

Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under Other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]