1. Gene
  2. IRF2BP1 - interferon regulatory factor 2 binding protein 1 Gene

IRF2BP1 - interferon regulatory factor 2 binding protein 1 Gene

中文名称:干扰素调节因子 2 结合蛋白 1

种属: Homo sapiens

基因 ID: 26145 | 基因类型: protein coding

关于 IRF2BP1

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,883,608-45,886,141 (from NCBI)

This gene has 1 transcript (splice variant), 225 orthologues and 5 paralogues.

功能概要

启用转录辅阻遏物活性和泛素蛋白连接酶活性。参与蛋白质多聚泛素化。在 RNA 聚合酶 II 的转录负调节上游或负调节内起作用。位于核质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables transcription corepressor activity and ubiquitin protein Ligase activity. Involved in protein polyubiquitination. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

IRF2BP1 基因产物(1)

mRNA Protein Name
NM_015649.3 NP_056464.1 interferon regulatory factor 2-binding protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18671972 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
12799427 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
18671972 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12799427 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18671972 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
18671972 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12799427 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IRF2BP1 蛋白结构

IRF-2BP1_2

IRF-2BP1_2: Interferon regulatory factor 2-binding protein zinc finger (7 - 59)

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (503 - 547)

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  • 584 a.a.
蛋白主名 其他名称

interferon regulatory factor 2-binding protein 1

IRF-2-binding protein 1

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta IRF2BP1 VGNC VGNC:73638
Rattus norvegicus IRF2BP1 RGD RGD:1308312
Canis familiaris IRF2BP1 VGNC VGNC:42093
Mus musculus IRF2BP1 MGD MGI:2442159