Map3k7 - mitogen-activated protein kinase kinase kinase 7 Gene

中文名称：丝裂原活化蛋白激酶激酶激酶 7

种属: Mus musculus

同用名: Tak1; B430101B05

关于 Map3k7

功能概要

该基因编码的蛋白可启动酶激活剂活性；蛋白激酶活性；和受体酪氨酸激酶结合活性。涉及几个进程，包括JNK级联；失巢凋亡；坏死过程的负调控。作用于多个过程的上游或内部，包括细胞内信号转导；调节信号转导；和管形态发生。位于突触后密度。以多种结构表达，包括中枢神经系统；直觉;后肾;生殖系统;和呼吸系统。用于研究 Wolff-Parkinson-White 综合症。该基因的人类直系同源物与额干骺端发育不良 2 和前列腺癌有关。与人 MAP3K7（丝裂原活化蛋白激酶激酶激酶 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Enzyme activator activity; protein kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including JNK cascade; anoikis; and negative regulation of necroptotic process. Acts upstream of or within several processes, including intracellular signal transduction; regulation of signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including central nervous system; gut; metanephros; reproductive system; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate Cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]