GDF10 - growth differentiation factor 10 Gene

中文名称：生长分化因子 10

种属: Homo sapiens

同用名: BIP; BMP3B; BMP-3b

关于 GDF10

功能概要

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同型二聚体的每个亚基。这促进了中风后的神经修复。此外，这种蛋白质可能充当肿瘤抑制因子，并且这种基因的表达减少与口腔癌有关。[RefSeq 提供，2016 年 7 月]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral Cancer. [provided by RefSeq, Jul 2016]