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  3. Acvr1c - activin A receptor, type IC Gene

Acvr1c - activin A receptor, type IC Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：激活素A受体， IC型

种属: Mus musculus

同用名: ALK7; Alk-7; ACTR-IC; ACVRLK7; C230097P10

基因 ID: 269275 | 基因类型: protein coding

关于 Acvr1c

Chromosome 2: 58,157,465-58,247,907 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 215 orthologues, 11 paralogues and is associated with 6 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 3.9), genital fat pad adult (RPKM 2.9) and 8 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 ATP 绑定活动； BMP受体结合活性；和激活素结合活性。在几个过程的上游或内部起作用，包括胰岛素分泌的负调节；对葡萄糖的反应；和对胰岛素的反应。预测位于细胞表面和细胞质中。预计是激活素受体复合物的一部分。预计在质膜上有活性。以多种结构表达，包括脂肪组织；肾上腺;消化系统；脑;和泌尿生殖系统。与人类 ACVR1C（1C 型激活素 A 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; BMP Receptor binding activity; and activin binding activity. Acts upstream of or within several processes, including negative regulation of Insulin secretion; response to glucose; and response to Insulin. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; brain; and genitourinary system. Orthologous to human ACVR1C (Activin A receptor type 1C). [provided by Alliance of Genome Resources, Apr 2022]

Acvr1c 基因产物(2)

mRNA Protein Name
NM_001111030.1 NP_001104500.1 activin receptor type-1C isoform 1 precursor
NM_001033369.3 NP_001028541.1 activin receptor type-1C isoform 2
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT acts upstream of or within determination of left/right symmetry IMP
IMP: 通过突变表型推断
15485907 MGI
NOT acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
15485907 MGI
acts upstream of insulin secretion IMP
IMP: 通过突变表型推断
18480258 MGI
acts upstream of or within lipid storage IMP
IMP: 通过突变表型推断
18480258 MGI
acts upstream of or within negative regulation of insulin secretion IMP
IMP: 通过突变表型推断
18480258 MGI
acts upstream of or within response to dietary excess IMP
IMP: 通过突变表型推断
18480259 MGI
acts upstream of or within response to glucose IMP
IMP: 通过突变表型推断
18480258 MGI
acts upstream of or within response to insulin IMP
IMP: 通过突变表型推断
18480259 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Acvr1c 蛋白结构

Activin_recp

Activin_recp: pfam01064 (26 - 94)

TGF_beta_GS

TGF_beta_GS: pfam08515 (165 - 192)

STKc_TGFbR1_ACVR1b_ACVR1c

STKc_TGFbR1_ACVR1b_ACVR1c: cd14143 (198 - 485)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
蛋白主名 其他名称

activin receptor type-1C

activin receptor type IC

activin receptor-like kinase 7

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00242 ACVR1C Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00243 Acvr1c Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00244 Acvr1c Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acvr1c NCBI NCBI:130399
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