TAF5L - TATA-box binding protein associated factor 5 like Gene

中文名称：TATA-box 结合蛋白相关因子 5

种属: Homo sapiens

同用名: PAF65B

关于 TAF5L

功能概要

该基因的产物属于 WD-repeat TAF5 蛋白家族。该基因编码的蛋白质是 PCAF 组蛋白乙酰化酶复合物的一个组成部分。 PCAF 组蛋白乙酰化酶复合物由 20 多种多肽组成，其中一些是 TAF，是肌源性转录和分化所必需的。 TAF 可能参与基础转录，作为共激活因子，在启动子识别中发挥作用或修饰一般转录因子以促进复杂的组装和转录起始。编码的蛋白质在结构上类似于一种组蛋白样 TAF，TAF5。已经为该基因鉴定了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]