2. Gene
  3. CHIA - chitinase acidic Gene

CHIA - chitinase acidic Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：几丁质酶酸性

种属: Homo sapiens

同用名: CHIT2; AMCASE; TSA1902

基因 ID: 27159 | 基因类型: protein coding

关于 CHIA

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,290,851-111,320,563 (from NCBI)

This gene has 10 transcripts (splice variants), 253 orthologues and 6 paralogues. Biased expression in stomach (RPKM 2.7), lung (RPKM 1.9) and 2 other tissues.

功能概要

由该基因编码的蛋白质可降解甲壳素，甲壳素存在于大多数真菌以及节肢动物和一些线虫的细胞壁中。编码的蛋白质还可以刺激白细胞介素 13 的表达，该基因的变异可导致哮喘易感性。已发现该基因的几种转录变体编码几种不同的亚型。[RefSeq 提供，2012 年 4 月]

The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

CHIA 基因产物(8)

mRNA Protein Name
NM_001040623.3 NP_001035713.1 acidic mammalian chitinase isoform b
NM_001258001.2 NP_001244930.1 acidic mammalian chitinase isoform a
NM_001258002.2 NP_001244931.1 acidic mammalian chitinase isoform b
NM_001258003.2 NP_001244932.1 acidic mammalian chitinase isoform a
NM_001258004.2 NP_001244933.1 acidic mammalian chitinase isoform b
NM_001258005.2 NP_001244934.1 acidic mammalian chitinase isoform b
NM_021797.4 NP_068569.2 acidic mammalian chitinase isoform a
NM_201653.4 NP_970615.2 acidic mammalian chitinase isoform c precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chitinase activity IDA
IDA: 通过直接分析推断
19435888 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
18824549 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18824549 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chitin catabolic process IDA
IDA: 通过直接分析推断
19435888 GOA
involved in positive regulation of chemokine production IDA
IDA: 通过直接分析推断
18824549 GOA
involved in production of molecular mediator involved in inflammatory response IDA
IDA: 通过直接分析推断
18824549 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
18824549 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHIA 蛋白结构

Glyco_hydro_18

Glyco_hydro_18: Glycosyl hydrolases family 18 (23 - 365)

CBM_14

CBM_14: Chitin binding Peritrophin-A domain (430 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
蛋白主名 其他名称

acidic mammalian chitinase

lung-specific protein TSA1902

CHIA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CHIA Q9BZP6 RBBP8NL Homo sapiens Q8NC74
Y2H Array
32296183
种属内
CHIA Q9BZP6 RBBP8NL Homo sapiens Q8NC74
Y2H Prey Pooling
32296183
种属内
CHIA Q9BZP6 COX20 Homo sapiens Q5RI15
Y2H Array
32296183
种属内
CHIA Q9BZP6 COX20 Homo sapiens Q5RI15
Y2H Prey Pooling
32296183
种属内
CHIA Q9BZP6 EGFR Homo sapiens P00533
Anti Bait CoIP
18824549
种属内
CHIA Q9BZP6 TBC1D5 Homo sapiens Q92609
Y2H Prey Pooling
32296183
种属内
CHIA Q9BZP6 TBC1D5 Homo sapiens Q92609
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CHIA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77869 AMCase/CHIA Protein, Human (HEK293, His) Q9BZP6 (Y22-A476) ≥95%

关联疾病

疾病名称 别名
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Gaucher'S Disease

Gaucher Disease

Kerasin Thesaurismosis

Glucocerebrosidase Deficiency

Glucosylceramidase Deficiency

Cerebroside Lipidosis Syndrome

Acid Beta-Glucosidase Deficiency

Glucosylceramide Beta-Glucosidase Deficiency

Acute Cerebral Gaucher Disease

Gaucher Splenomegaly

Glucocerebrosidosis

Glucosyl Cerebroside Lipidosis

Kerasin Lipoidosis

Lipoid Histiocytosis

Glocucerebrosidase Deficiency

Sphingolipidosis 1

Gaucher Syndrome

Gauchers Disease

Gd

Glucosylceramide Lipidosis

Kerasin Histiocytosis

Gaucher Disease, Type 1

Gaucher Disease, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N7624 Methyl oleanonate Agonist 99.81% 否
HY-N7003 28-Demethyl-β-amyrone Inhibitor / 否
HY-RS02628 CHIA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CHIA VGNC VGNC:55040
Canis familiaris CHIA VGNC VGNC:39214
Mus musculus CHIA MGD MGI:1932052
Rattus norvegicus CHIA RGD RGD:1303058
Macaca mulatta CHIA VGNC VGNC:70969
Felis catus CHIA VGNC VGNC:60856
Others CHIA NCBI
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