2. Gene
  3. NAAA - N-acylethanolamine acid amidase Gene

NAAA - N-acylethanolamine acid amidase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：N-酰基乙醇胺酸酰胺酶

种属: Homo sapiens

同用名: PLT; ASAHL

基因 ID: 27163 | 基因类型: protein coding

关于 NAAA

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,910,655-75,941,013 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in prostate (RPKM 15.8), colon (RPKM 14.0) and 24 other tissues.

功能概要

该基因编码一种与酸性神经酰胺酶高度相似的 N-酰基乙醇胺水解酶。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes an N-acylethanolamine-hydrolyzing Enzyme which is highly similar to acid Ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NAAA 基因产物(3)

mRNA Protein Name
NM_001042402.2 NP_001035861.1 N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor
NM_001363719.2 NP_001350648.1 N-acylethanolamine-hydrolyzing acid amidase isoform 2 precursor
NM_014435.4 NP_055250.2 N-acylethanolamine-hydrolyzing acid amidase isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
21106534 GOA
enables N-(long-chain-acyl)ethanolamine deacylase activity IDA
IDA: 通过直接分析推断
15655246 GOA
enables N-acylsphingosine amidohydrolase activity IDA
IDA: 通过直接分析推断
15655246 GOA
enables fatty acid amide hydrolase activity IDA
IDA: 通过直接分析推断
15655246 GOA
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IDA
IDA: 通过直接分析推断
17980170 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-acylethanolamine metabolic process IDA
IDA: 通过直接分析推断
15655246 GOA
involved in N-acylphosphatidylethanolamine metabolic process IDA
IDA: 通过直接分析推断
22825852 GOA
involved in fatty acid metabolic process IDA
IDA: 通过直接分析推断
15655246 GOA
involved in sphingosine metabolic process IDA
IDA: 通过直接分析推断
15655246 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10610717 GOA
located in lysosome IDA
IDA: 通过直接分析推断
15655246 GOA
located in membrane IDA
IDA: 通过直接分析推断
30301806 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAAA 蛋白结构

NAAA-beta

NAAA-beta: beta subunit of N-acylethanolamine-hydrolyzing acid amidase (33 - 121)

CBAH

CBAH: Linear amide C-N hydrolases, choloylglycine hydrolase family (126 - 292)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
蛋白主名 其他名称

N-acylethanolamine-hydrolyzing acid amidase

ASAH-like protein

关联疾病

疾病名称 别名
Bleeding Disorder, Platelet-Type, 12

BDPLT12

Prostaglandin-Endoperoxide Synthase 1 Deficiency, Platelet

Pghs1 Deficiency

Platelet Cyclooxygenase 1 Deficiency

Platelet Cox1 Deficiency

Platelet-Type Bleeding Disorder 12

Platelet Prostaglandin-Endoperoxide Synthase 1 Deficiency
Vulvar Syringoma
Noonan Syndrome 10

NS10

Noonan Syndrome, Type 10
Charcot-Marie-Tooth Disease, Type 4j

Charcot-Marie-Tooth Disease Type 4j

CMT4J

Charcot-Marie-Tooth Disease, Autosomal Recessive, Type 4j

Autosomal Recessive Charcot-Marie-Tooth Disease Type 4j

Charcot-Marie-Tooth Disease 4j
Yunis-Varon Syndrome

Cleidocranial Dysplasia With Micrognathia, Absent Thumbs, And Distal Aphalangia

Yunis Varon Syndrome

YVS

Cleidocranial Dysplasia-Micrognathia-Absent Thumbs Syndrome

Cleidocranial Dysplasia, Micrognathia, Absent Thumbs, & Distal Aphalangia

Yunis-Varón Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0182 Carmofur Inhibitor 99.95% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-121975 N-Cyclohexanecarbonylpentadecylamine Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W074890 Palmitoylglycine Modulator 99.74% 否
HY-145339 ARN19702 99.80% 否
HY-120813 ARN 077 Inhibitor 98.83% 否
HY-147773 NAAA-IN-1 Inhibitor 99.65% 否
HY-124597 ARN726 95.00% 否
HY-132882 ARN19689 Inhibitor / 否
HY-120813A ARN 077 (enantiomer) 99.71% 否
HY-125384 ARN14686 / 否
HY-147775 NAAA-IN-3 / 否
HY-D2338 PMBD / 否
HY-RS08993 NAAA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-157223 ARN16186 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NAAA VGNC VGNC:75068
Mus musculus NAAA MGD MGI:1914361
Felis catus NAAA VGNC VGNC:68327
Bos taurus NAAA VGNC VGNC:31854
Rattus norvegicus NAAA RGD RGD:1307267
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