GPR78 - G protein-coupled receptor 78 Gene

中文名称：G 蛋白偶联受体 78

种属: Homo sapiens

关于 GPR78

功能概要

该基因编码的蛋白属于 G 蛋白偶联受体家族，包含 7 个跨膜结构域，通过异源三聚体 G 蛋白转导细胞外信号。这是一种孤儿受体，显示出显着水平的组成性活性。关联分析显示该基因参与双相情感障碍和精神分裂症易感性的初步证据。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an Orphan Receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]