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  2. GPR78 - G protein-coupled receptor 78 Gene

GPR78 - G protein-coupled receptor 78 Gene

中文名称:G 蛋白偶联受体 78

种属: Homo sapiens

基因 ID: 27201 | 基因类型: protein coding

关于 GPR78

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:8,580,392-8,590,023 (from NCBI)

This gene has 7 transcripts (splice variants), 171 orthologues and 3 paralogues. Biased expression in placenta (RPKM 2.0), esophagus (RPKM 0.8) and 1 other tissue.

功能概要

该基因编码的蛋白属于 G 蛋白偶联受体家族,包含 7 个跨膜结构域,通过异源三聚体 G 蛋白转导细胞外信号。这是一种孤儿受体,显示出显着水平的组成性活性。关联分析显示该基因参与双相情感障碍和精神分裂症易感性的初步证据。已发现该基因的可变剪接转录物变体。[RefSeq 提供,2011 年 11 月]

The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an Orphan Receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

GPR78 基因产物(1)

mRNA Protein Name
NM_080819.5 NP_543009.2 G-protein coupled receptor 78
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
17363172 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26940976 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
17363172 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GPR78 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (23 - 294)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
蛋白主名 其他名称

G-protein coupled receptor 78

关联疾病

疾病名称 别名
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma