2. Gene
  3. TOX3 - TOX high mobility group box family member 3 Gene

TOX3 - TOX high mobility group box family member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TOX 高机动性组盒家族成员 3

种属: Homo sapiens

同用名: CAGF9; TNRC9

基因 ID: 27324 | 基因类型: protein coding

关于 TOX3

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:52,436,416-52,547,802 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 20 paralogues. Biased expression in stomach (RPKM 5.0), colon (RPKM 3.6) and 13 other tissues.

功能概要

该基因编码的蛋白质含有一个 HMG-box，表明它可能参与 DNA 的弯曲和解旋以及染色质结构的改变。由于编码序列中的 CAG 重复，编码蛋白的 C 端富含谷氨酰胺。该基因的一个次要等位基因与乳腺癌风险升高有关。已发现该基因编码不同亚型的两个转录变体。[RefSeq 提供，2009 年 4 月]

The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast Cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

TOX3 基因产物(2)

mRNA Protein Name
NM_001080430.4 NP_001073899.2 TOX high mobility group box family member 3 isoform 1
NM_001146188.2 NP_001139660.1 TOX high mobility group box family member 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
21172805 GOA
enables phosphoprotein binding IPI
IPI: 通过物理相互作用推断
21172805 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21172805 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
21172805 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
21172805 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
21172805 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21172805 GOA
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
21172805 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TOX3 蛋白结构

HMG_box

HMG_box: HMG (high mobility group) box (255 - 323)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 576 a.a.
蛋白主名 其他名称

TOX high mobility group box family member 3

CAG trinucleotide repeat-containing gene F9 protein

关联疾病

疾病名称 别名
Restless Legs Syndrome

Wed

Willis-Ekbom Disease

Restless Leg Syndrome

Ekbom Syndrome

Wittmaack-Ekbom Syndrome

Willis Ekbom Disease

Ekbom'S Syndrome

Rls

Restless Legs

Restless Legs Syndrome, Susceptibility To
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Sporadic Breast Cancer

Sporadic Breast Carcinoma
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14910 TOX3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TOX3 VGNC VGNC:55004
Mus musculus TOX3 MGD MGI:3039593
Macaca mulatta TOX3 VGNC VGNC:78612
Rattus norvegicus TOX3 RGD RGD:1311529
Bos taurus TOX3 VGNC VGNC:36229
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